Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database

M Moriel Singer-Berk S Sarah L. Stenton J Julia K. Goodrich M Michael W. Wilson J Jonah Einson M Maria Abreu A Amina Abubakar R Rolf Adolfsson C Carlos A. Aguilar Salinas T Tariq Ahmad C Christine M. Albert (Department of Cardiology, Smidt Heart Institute, Cedars–Sinai Medical Center, Los Angeles) J Jessica Alföldi M Matthieu Allez C Celso Arango López D Diego Ardissino I Irina M. Armean E Elizabeth G. Atkinson G Gil Atzmon E Eric Banks J John Barnard S Samantha M. Baxter L Laurent Beaugerie D David Benjamin E Emelia J. Benjamin L Louis Bergelson C Charles Bernstein D Douglas Blackwood M Michael Boehnke L Lori L. Bonnycastle E Erwin P. Bottinger D Donald W. Bowden M Matthew J. Bown H Harrison Brand S Steven Brant T Ted Brookings S Sam Bryant S Shawneequa L. Callier H Hannia Campos J John C. Chambers J Juliana C. Chan K Katherine R. Chao S Sinéad Chapman D Daniel I. Chasman L Lea A. Chen S Siwei Chen R Rex Chisholm J Judy Cho R Rajiv Chowdhury M Mina K. Chung W Wendy K. Chung (Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School) K Kristian Cibulskis B Bruce Cohen R Ryan L. Collins K Kristen M. Connolly A Adolfo Correa A Aiden Corvin M Miguel Covarrubias N Nick Craddock B Beryl B. Cummings D Dana Dabelea M Mark J. Daly J John Danesh D Dawood Darbar P Phil Darnowsky J Joshua C. Denny S Stacey Donnelly R Richard H. Duerr R Ravindranath Duggirala J Josée Dupuis P Patrick T. Ellinor R Roberto Elosua J James Emery E Eleina England J Jeanette Erdmann T Tõnu Esko E Emily Evangelista Y Yossi Farjoun D Diane Fatkin W William Faubion S Steven Ferriera G Gemma Figtree K Kelly Flannagan J Jose Florez L Laurent Francioli A Andre Franke A Adam Frankish J Jack Fu M Martti Färkkilä S Stacey Gabriel K Kiran Garimella L Laura D. Gauthier J Jeff Gentry M Michel Georges G Gad Getz D David C. Glahn B Benjamin Glaser S Stephen J. Glatt F Fernando S. Goes D David Goldstein C Clicerio Gonzalez J Julia Goodrich R Riley H. Grant L Leif Groop S Sanna Gudmundsson N Namrata Gupta (Broad Institute of MIT and Harvard, Cambridge, MA, USA.) A Andrea Haessly C Christopher Haiman I Ira Hall C Craig L. Hanis J James Hanyok M Matthew Harms Q Qin He (State Key Laboratory of Soil Pollution Control and Safety, Department of Chemistry) M Mikko Hiltunen M Matti M. Holi C Christina M. Hultman S Steve Jahl C Chaim Jalas T Thibault Jeandet M Mikko Kallela D Diane Kaplan J Jaakko Kaprio K Konrad J. Karczewski E Elizabeth W. Karlson S Sekar Kathiresan (Verve Therapeutics, a wholly owned subsidiary of Eli Lilly, Boston) E Eimear E. Kenny B Bong-Jo Kim Y Young Jin Kim D Daniel King G George Kirov Z Zan Koenig J Jaspal Kooner S Seppo Koskinen H Harlan M. Krumholz S Subra Kugathasan J Juozas Kupcinskas S Soo Heon Kwak M Markku Laakso N Nicole Lake M Mikael Landén T Trevyn Langsford K Kristen M. Laricchia T Terho Lehtimäki M Monkol Lek (Department of Genetics, Yale School of Medicine) J James Lewis C Cecilia M. Lindgren E Emily Lipscomb C Christopher Llanwarne R Ruth J. F. Loos E Edouard Louis C Chelsea Lowther W Wenhan Lu S Steven A. Lubitz T Tom Lyons R Ronald C. W. Ma D Dara S. Manoach G Gregory M. Marcus (Division of Cardiology, University of California, San Francisco, San Francisco) J Jaume Marrugat N Nicholas Marston D Daniel M. Marten A Alicia R. Martin K Kari M. Mattila S Steven McCarroll M Mark I. McCarthy J Jacob L. McCauley D Dermot McGovern R Ruth McPherson A Andrew MacQuillin J James B. Meigs O Olle Melander A Andres Metspalu D Deborah Meyers E Eric V. Minikel B Braxton D. Mitchell P Paul Moayyedi (Farncombe Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada) S Sanghamitra Mohanty A Andrés Moreno Estrada N Nicola J. Mulder R Ruchi Munshi A Aliya Naheed A Andrea Natale (Texas Cardiac Arrhythmia Research, St. David’s Medical Center, Austin) S Saman Nazarian B Benjamin M. Neale C Charles Newton P Peter M. Nilsson S Sam Novod A Anne H. O’Donnell-Luria M Michael C. O’Donovan Y Yukinori Okada D Dost Ongur R Roel Ophoff L Lorena Orozco W Willem Ouwehand M Michael J. Owen N Nick Owen C Colin Palmer N Nicholette D. Palmer A Aarno Palotie M Mara Parellada K Kyong Soo Park C Carlos Pato N Nancy L. Pedersen T Tina Pesaran N Nikelle Petrillo W William Phu S Sharon Plon D Danielle Posthuma T Timothy Poterba A Ann E. Pulver A Aaron Quinlan D Dan Rader N Nazneen Rahman H Heidi Rehm A Andreas Reif A Alex Reiner (Department of Epidemiology, University of Washington, Seattle, WA, USA.) A Anne M. Remes D Dan Rhodes S Stephen Rich J John D. Rioux S Samuli Ripatti D David Roazen J Jason Roberts E Elise Robinson (Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University) D Dan M. Roden J Jerome I. Rotter G Guy Rouleau V Valentin Ruano-Rubio C Christian T. Ruff H Heiko Runz M Marc S. Sabatine (TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston) N Nareh Sahakian D Danish Saleheen V Veikko Salomaa A Andrea Saltzman N Nilesh J. Samani K Kaitlin E. Samocha A Alba Sanchis-Juan A Akira Sawa J Jeremiah Scharf M Molly Schleicher P Patrick Schultz H Heribert Schunkert (DZHK Partner Site Munich, Munich Heart Alliance, Munich, Germany) S Sebastian Schönherr E Eleanor G. Seaby C Cotton Seed S Svati H. Shah M Megan Shand T Ted Sharpe M Moore B. Shoemaker T Tai Shyong E Edwin K. Silverman (Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.) J Jurgita Skiecevičienė P Pamela Sklar J J. Gustav Smith J Jonathan T. Smith J Jordan Smoller H Hilkka Soininen H Harry Sokol M Matthew Solomonson R Rachel G. Son J Jose Soto T Tim Spector D David St Clair C Christine Stevens N Nathan O. Stitziel (From the Cardiovascular Division, Department of Medicine, and the Department of Genetics, Washington University School of Medicine, St. Louis.) P Patrick F. Sullivan J Jaana Suvisaari E E. Shyong Tai M Michael E. Talkowski Y Yekaterina Tarasova K Kent D. Taylor (The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.) Y Yik Ying Teo G Grace Tiao K Kathleen Tibbetts C Charlotte Tolonen M Ming Tsuang T Tiinamaija Tuomi D Dan Turner T Teresa Tusie-Luna E Erkki Vartiainen M Marquis Vawter S Séverine Vermeire E Elisabet Vilella C Christopher Vittal G Gordon Wade M Mark Walker A Arcturus Wang L Lily Wang Q Qingbo Wang J James S. Ware H Hugh Watkins N Nicholas A. Watts R Rinse K. Weersma B Ben Weisburd M Maija Wessman C Christopher Whelan N Nicola Whiffin J James G. Wilson L Lauren Witzgall R Ramnik J. Xavier M Mary T. Yohannes R Robert Yolken X Xuefang Zhao T Tuuli Lappalainen H Heidi L. Rehm D Daniel G. MacArthur A Anne O’Donnell-Luria