Expert Opinion on the Diagnosis and Treatment of Hematologic Malignancies During Pregnancy

D Daan Dierickx (6University Hospitals Leuven, Leuven, Belgium) J Joosje H. Heimovaara (Department of Oncology, KU Leuven, Leuven, Belgium) M Mar Bellido (13University Medical Center Groningen and University of Groningen, Groningen, Netherlands) K Kristel Van Calsteren (Division of Fetomaternal Medicine, Department of Obstetrics and Gynecology, UZ Leuven, Leuven, Belgium) E Elyce Cardonick (Department of Obstetrics and Gynecology, Cooper, University Health Care, Camden, NJ) A Alvaro Cabrera Garcia (Hospital Regional de Alta Especialidad de Ixtapaluca (HRAEI) “Reference Clinic for Hemato-oncological Diseases During Pregnancy CREHER” Estado de México, Ixtapaluca, Mexico) A Adinda Baten (Department of Radiation Oncology University Hospitals Leuven Leuven Belgium) A Andrew M. Evens (Division of Blood Disorders, Rutgers Cancer Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ) A Andres Ferber (Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA) M Monica Fumagalli E Elzbieta Lampka (The Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland) L Lena Specht (Copenhagen University Hospital–Rigshospitalet) V Vincent Vandecaveye (Department of Radiology, University Hospitals Leuven, Leuven, Belgium) I Ivan R. Vogelius (Department of Radiation Oncology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark) M Markus Alber (Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany) F Frédéric Amant

Abstract

The diagnosis and treatment of hematologic malignancies has undergone significant advancements over the past few decades, resulting in enhanced outcomes. For hematologic malignancies diagnosed during pregnancy, this poses new questions. As possibilities continue to expand and the rising global incidence results in an increasing number of diagnoses within the pregnant population, there is a pressing need to gain a deeper understanding of the potential options for pregnant women and the impact on the newborn. As knowledge of the effects of cancer treatment increases, more women are receiving adequate cancer diagnosis and treatment during pregnancy. This paper presents an expert opinion on the use of diagnostic modalities and treatment options, including chemotherapy, radiation therapy, and immunotherapy, for acute leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, myeloproliferative neoplasms, aplastic anemia, and multiple myeloma during pregnancy.

Article Details

Volume / Issue Vol. 44, Issue 18
Published June 20, 2026
Pages 1730-1744
ISSN 0732-183X
Publisher Lippincott Williams & Wilkins

Journal Info

Journal of Clinical Oncology

Lippincott Williams & Wilkins

ISSN: 0732-183X Health Sciences

Authors (16)

D

Daan Dierickx

6University Hospitals Leuven, Leuven, Belgium

J

Joosje H. Heimovaara

Department of Oncology, KU Leuven, Leuven, Belgium

M

Mar Bellido

13University Medical Center Groningen and University of Groningen, Groningen, Netherlands

K

Kristel Van Calsteren

Division of Fetomaternal Medicine, Department of Obstetrics and Gynecology, UZ Leuven, Leuven, Belgium

E

Elyce Cardonick

Department of Obstetrics and Gynecology, Cooper, University Health Care, Camden, NJ

A

Alvaro Cabrera Garcia

Hospital Regional de Alta Especialidad de Ixtapaluca (HRAEI) “Reference Clinic for Hemato-oncological Diseases During Pregnancy CREHER” Estado de México, Ixtapaluca, Mexico

A

Adinda Baten

Department of Radiation Oncology University Hospitals Leuven Leuven Belgium

A

Andrew M. Evens

Division of Blood Disorders, Rutgers Cancer Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ

A

Andres Ferber

Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA

M

Monica Fumagalli

E

Elzbieta Lampka

The Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland

L

Lena Specht

Copenhagen University Hospital–Rigshospitalet

V

Vincent Vandecaveye

Department of Radiology, University Hospitals Leuven, Leuven, Belgium

I

Ivan R. Vogelius

Department of Radiation Oncology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

M

Markus Alber

Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany

F

Frédéric Amant