Expanding the payload scope in antibody-drug conjugates by delivery of hydroxy-containing drugs through self-immolative phosphoramidates

P Philipp Ochtrop A Anil P. Jagtap J Jan G. Felber S Simon Vogt S Sarah Herterich I Isabelle Mai P Philipp Cyprys S Saskia Schmitt (Tubulis GmbH, Am Klopferspitz 19a, Planegg-Martinsried, Munich, 82152 Germany) S Sarah Payer A Annabel Kitowski S Swetlana Wunder P Paul Machui J Julia Brandmeier N Natascia Leonardi E Elizaveta Poliak C Christian P. R. Hackenberger (Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125 Berlin, Germany) O Olivier Marcq D Dominik Schumacher (Tubulis GmbH, Am Klopferspitz 19a, Planegg-Martinsried, Munich, 82152 Germany) J Jonas Helma (Tubulis GmbH, Am Klopferspitz 19a, Planegg-Martinsried, Munich, 82152 Germany) A Annette M. Vogl M Marc-André Kasper (Tubulis GmbH, Am Klopferspitz 19a, Planegg-Martinsried, Munich, 82152 Germany)

Article Details

Volume / Issue Vol. 17, Issue 1
Published January 20, 2026
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (21)

P

Philipp Ochtrop

A

Anil P. Jagtap

J

Jan G. Felber

S

Simon Vogt

S

Sarah Herterich

I

Isabelle Mai

P

Philipp Cyprys

S

Saskia Schmitt

Tubulis GmbH, Am Klopferspitz 19a, Planegg-Martinsried, Munich, 82152 Germany

S

Sarah Payer

A

Annabel Kitowski

S

Swetlana Wunder

P

Paul Machui

J

Julia Brandmeier

N

Natascia Leonardi

E

Elizaveta Poliak

C

Christian P. R. Hackenberger

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125 Berlin, Germany

O

Olivier Marcq

D

Dominik Schumacher

Tubulis GmbH, Am Klopferspitz 19a, Planegg-Martinsried, Munich, 82152 Germany

J

Jonas Helma

Tubulis GmbH, Am Klopferspitz 19a, Planegg-Martinsried, Munich, 82152 Germany

A

Annette M. Vogl

M

Marc-André Kasper

Tubulis GmbH, Am Klopferspitz 19a, Planegg-Martinsried, Munich, 82152 Germany