Examination of the impact of curiosity and fatigue on brain condition

Y Yan Ni (Department of Endocrinology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health) K Keisuke Kokubun K Kiyotaka Nemoto (Department of Medical Informatics and Management and Psychiatry, Institute of Medicine, University of Tsukuba) Y Yoshinori Yamakawa

Abstract

Abstract With a growing emphasis on cognitive well-being, this study investigates factors influencing brain health, measured by Fractional Anisotropy Brain Healthcare Quotient (FA-BHQ). We find a positive correlation between curiosity, assessed by the Curiosity and Exploration Inventory-II (CEI-II), and brain health as indicated by FA-BHQ. Conversely, fatigue, evaluated using the Chalder Fatigue Scale (CFS), demonstrates a negative correlation with brain health. Furthermore, curiosity and fatigue serve as significant mediators in the relationship between these factors and FA-BHQ, respectively. Specific brain regions, including the corpus callosum, internal capsule, fornix, and posterior thalamic radiation, show significant negative correlations with fatigue, while the corpus callosum, fornix, internal capsule, corona radiata, external capsule, cingulum, and posterior thalamic radiation exhibit significant positive correlations with curiosity. Notably, this study highlights that more brain regions exhibit significant correlations with curiosity compared to fatigue, shedding light on the growing recognition of curiosity’s role in influencing brain health and emphasizing the importance of considering curiosity in the research on cognitive well-being.

Article Details

Volume / Issue Vol. 15, Issue 1
Published April 15, 2025
ISSN 2045-2322
Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (4)

Y

Yan Ni

Department of Endocrinology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health

K

Keisuke Kokubun

K

Kiyotaka Nemoto

Department of Medical Informatics and Management and Psychiatry, Institute of Medicine, University of Tsukuba

Y

Yoshinori Yamakawa