Enhanced feature dynamic fusion gated UNet for robust retinal vessel segmentation

Y Yang Yang Y Yifeng Li J Jikui Wang H Haibo Zhou W Weihua Zhang X Xing Chen (Institute of Molecular Plus, Department of Chemistry, Tianjin University and Haihe Laboratory of Sustainable Chemical Transformations, 92 Weijin Road, Tianjin 300072, China) T Tianyun Luan W Wanting Liu D Dashi Ying

Abstract

Abstract This study proposes a Deep learning model, the Enhanced Feature Dynamic Fusion-Gated U-Net (EFDG-UNet), for retinal vessel segmentation. To address challenges in segmenting small vessels, handling lesion interference, and adapting to multi-scale structures, the model incorporates optimized feature fusion, dynamic selection, and global position modeling. The Feature Navigation Hub (FN-Hub) captures long-range dependencies across multiple encoder layers, improving multi-scale vessel segmentation. The Adaptive Gated Residual Block (AGRB) uses a dynamic gating mechanism to enhance feature selectivity in lesion areas and low-contrast scenarios. The Parallel Focused Attention Module (PFAM) optimizes channel and spatial information for fine-grained vessel features. Experimental validation on DRIVE, CHASE_DB1, and STARE datasets shows that EFDG-UNet achieves state-of-the-art performance, attaining an AUC of 0.9932 and F1-score of 0.8469 on CHASE_DB1, and an AUC of 0.9886 and F1-score of 0.8412 on DRIVE. The model shows improved performance in low-contrast regions and complex vessel structures compared to baseline methods.

Article Details

Volume / Issue Vol. 16, Issue 1
Published December 26, 2025
ISSN 2045-2322
Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (9)

Y

Yang Yang

Y

Yifeng Li

J

Jikui Wang

H

Haibo Zhou

W

Weihua Zhang

X

Xing Chen

Institute of Molecular Plus, Department of Chemistry, Tianjin University and Haihe Laboratory of Sustainable Chemical Transformations, 92 Weijin Road, Tianjin 300072, China

T

Tianyun Luan

W

Wanting Liu

D

Dashi Ying