Engineered Stem Cell Booster Breaks Pathological Barriers to Treat Chronic Pancreatitis
Abstract
AbstractChronic pancreatitis (CP) is a long‐standing progressive fibrosis and has long been considered incurable, which remains a heavy health burden worldwide. Mesenchymal stem cells (MSCs) with anti‐fibrosis properties are currently used in the treatment of fibroinflammatory diseases. However, its therapeutic effect is limited mainly due to two main types of pathological barriers in CP: 1) Fibrotic collagen hinders cell delivery, and 2) Malignant microenvironment attacks cell inactivation. Here, a MSCs‐based exogenous nitric oxide (NO) delivery system (MSCs‐Lip@RNO) is constructed. In the MSCs‐Lip@RNO, NO not only can be a cell booster to regulate collagen fibers, relieve the vascular compression and enhance the accumulation of MSCs in the whole pancreas, but also can form a protective gas layer on the cell surface, which enhances the therapeutic effect of MSCs. In the CP rat model, the pancreatic injury and fibrosis are reduced with 7 days after a single dose administration of this long‐acting MSCs. Collectively, this study offers a promising strategy for enhancing the delivery and therapeutic efficacy of MSCs to break pathological barriers in CP treatment.
Article Details
Authors (17)
Han Han
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States
Bi‐Te Chen
State Key Laboratory of Natural Medicines Department of Pharmaceutics China Pharmaceutical University Nanjing 210009 P. R. China
Yang Liu
Liang Qi
National Engineering Research Center of Lower-Carbon Catalysis Technology
Lei Xing
Department of Radiation Oncology, Stanford University
Hui Wang
Min Zhao
Chen Zhang
Shenzhen Institute for Quantum Science and Engineering, Department of Chemistry, and Department of Physics
Ping Yu
Beijing National Laboratory for Molecular Science, Key Laboratory of Analytical Chemistry for Living Biosystems
Ning Wei
Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment and Technology
Jing Wang
Hunan Cancer Hospital Changsha China
Fang Zhou
Institute of Hydrobiology, Chinese Academy of Sciences
Guang‐Ji Wang
Key Laboratory of Drug Metabolism and Pharmacokinetics Haihe Laboratory of Cell Ecosystem State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing 210009 China
Xian‐Wu Cheng
Department of Cardiology and Hypertension Yanbian University Hospital Yanji 133000 P. R. China
Zhang‐Jian Huang
State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases Center of Drug Discovery China Pharmaceutical University Nanjing 210009 P. R. China
Ling Li
Hu‐Lin Jiang
State Key Laboratory of Natural Medicines Department of Pharmaceutics China Pharmaceutical University Nanjing 210009 China