Engineered circular guide RNAs enhance miniature CRISPR/Cas12f-based gene activation and adenine base editing

Xin Zhang; Mengrao Li; Kechen Chen; Yuchen Liu; Jiawei Liu; Jiahong Wang; Hongxin Huang; Yanqun Zhang; Tao Huang; Shufeng Ma; Kaitong Liao; Jiayi Zhou; Mei Wang; Ying Lin; Zhili Rong

doi:10.1038/s41467-025-58367-4

Engineered circular guide RNAs enhance miniature CRISPR/Cas12f-based gene activation and adenine base editing

X Xin Zhang M Mengrao Li K Kechen Chen Y Yuchen Liu J Jiawei Liu J Jiahong Wang (School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China) H Hongxin Huang Y Yanqun Zhang T Tao Huang S Shufeng Ma K Kaitong Liao J Jiayi Zhou (Vir Biotechnology Inc.) M Mei Wang (School of Materials Science and Engineering, Institute for New Energy Materials & Low Carbon Technologies) Y Ying Lin (Induced Proximity Platform, Amgen Research) Z Zhili Rong

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published March 28, 2025

DOI 10.1038/s41467-025-58367-4

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (15)

X

Xin Zhang

M

Mengrao Li

K

Kechen Chen

Y

Yuchen Liu

J

Jiawei Liu

J

Jiahong Wang

School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

H

Hongxin Huang

Y

Yanqun Zhang

T

Tao Huang

S

Shufeng Ma

K

Kaitong Liao

J

Jiayi Zhou

Vir Biotechnology Inc.

M

Mei Wang

School of Materials Science and Engineering, Institute for New Energy Materials & Low Carbon Technologies

Y

Ying Lin

Induced Proximity Platform, Amgen Research

Z

Zhili Rong

Engineered circular guide RNAs enhance miniature CRISPR/Cas12f-based gene activation and adenine base editing

Article Details

Journal Info

Authors (15)

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