Endothelial PDLIM5 promotes tip cell filopodia formation and tumor angiogenesis by regulating ACTN1/ACTN4-dependent actin bundling

Zhiyong Xu; Yueli Shi; Yan Yang; Bufu Tang; Jiangnan Zhao; Mingshu Xiao; Sujing Jiang; Xinyuan Jiang; Nueraili Maihemuti; Kaiyue Zhang; Huan Wang; Yun Xu; Yuchao Sun; Xiuying Chen; Peng Xiao; Haiyan Xu; Hongqiang Cheng; Kai Wang

doi:10.1038/s41467-026-68765-x

Endothelial PDLIM5 promotes tip cell filopodia formation and tumor angiogenesis by regulating ACTN1/ACTN4-dependent actin bundling

Z Zhiyong Xu Y Yueli Shi Y Yan Yang B Bufu Tang (Department of Radiation Oncology, Zhongshan Hospital, Fudan University) J Jiangnan Zhao M Mingshu Xiao S Sujing Jiang X Xinyuan Jiang N Nueraili Maihemuti K Kaiyue Zhang H Huan Wang Y Yun Xu (Department of Radiology, Tongji Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine) Y Yuchao Sun X Xiuying Chen P Peng Xiao H Haiyan Xu H Hongqiang Cheng K Kai Wang

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published January 28, 2026

DOI 10.1038/s41467-026-68765-x

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (18)

Z

Zhiyong Xu

Y

Yueli Shi

Y

Yan Yang

B

Bufu Tang

Department of Radiation Oncology, Zhongshan Hospital, Fudan University

J

Jiangnan Zhao

M

Mingshu Xiao

S

Sujing Jiang

X

Xinyuan Jiang

N

Nueraili Maihemuti

K

Kaiyue Zhang

H

Huan Wang

Y

Yun Xu

Department of Radiology, Tongji Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine

Y

Yuchao Sun

X

Xiuying Chen

P

Peng Xiao

H

Haiyan Xu

H

Hongqiang Cheng

K

Kai Wang

Endothelial PDLIM5 promotes tip cell filopodia formation and tumor angiogenesis by regulating ACTN1/ACTN4-dependent actin bundling

Article Details

Journal Info

Authors (18)

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