Enantioselective Spirocyclization of Pd‐Enolates and Isocyanates
Abstract
AbstractAn enantioselective cyclization of Pd‐enolates and isocyanates to form spirocyclic γ‐lactams is reported. This reaction proceeds under mild reaction conditions and utilizes a novel Meldrum's acid derivative to achieve catalyst turnover, delivering enantioenriched products in up to 97% yield and 96% ee. Preliminary mechanistic investigations suggest that the reaction may proceed via the formation of higher‐order species.
Article Details
Authors (5)
Jay P. Barbor
Division of Chemistry and Chemical Engineering California Institute of Technology 1200 E. California Blvd, MC 101–20 Pasadena CA 91125 USA
Kaylin N. Flesch
Division of Chemistry and Chemical Engineering California Institute of Technology 1200 E. California Blvd, MC 101–20 Pasadena CA 91125 USA
Melinda Chan
Division of Chemistry and Chemical Engineering California Institute of Technology 1200 E. California Blvd, MC 101–20 Pasadena CA 91125 USA
Hannah R. Ang
Division of Chemistry and Chemical Engineering California Institute of Technology 1200 E. California Blvd, MC 101–20 Pasadena CA 91125 USA
Brian M. Stoltz
The Warren and Katherine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd, MC 101-20, Pasadena, California 91125, United States