Electrochemical Benzylic C─H Sulfation beyond the <i>O</i> ‐Sulfonation Limitation
Abstract
Abstract Direct C─H sulfation represents a valuable transformation for the synthesis of organosulfates. However, it has been challenging to achieve owing to the presence of multiple C─H bonds with comparable strengths and steric environments. Current methods for producing organosulfates primarily rely on O ‐sulfonation, which limits their applicability to hydroxyl‐containing compounds. Herein, we report a practical and cost‐efficient method for the electrochemical sulfation of benzylic C─H bonds. This reaction avoids the need for strong oxidants, demonstrating broad substrate scope, excellent chemoselectivity, and site selectivity. The orthogonal reactivity of this protocol is particularly evident in the transformation of alcohol substrates.
Article Details
Authors (5)
Wei Sheng
Huanhuan Peng
State Key Laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P.R. China
Ben Gao
State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Chunlan Song
State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering
Jiakun Li
State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering