Efficient Glycine Electrosynthesis via CO<sub>2</sub>‐Recyclable Hydrogen Donation on Pb/Pb<sub>7</sub>Bi<sub>3</sub> Heterointerfaces

P Pengsong Li (Institute of Chemistry, Chinese Academy of Sciences , , ,) Y Yong Wang X Xiangda Zhang (Beijing National Laboratory for Molecular Sciences, CAS Laboratory of Colloid and Interface and Thermodynamics, CAS Re‐search/Education Center for Excellence in Molecular Sciences, Center for Carbon Neutral Chemistry, Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P.R. China) C Congyang Wang (University of Chinese Academy of Sciences , , ,) Y Yuqing Hou (Institute of Chemistry, Chinese Academy of Sciences , , ,) G Ganwen Zhang (Institute of Chemistry, Chinese Academy of Sciences , , ,) X Xihua Wang L Lihong Jing (Beijing National Laboratory for Molecular Sciences, CAS Laboratory of Colloid and Interface and Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Center for Carbon Neutral Chemistry) Q Qingli Qian (Beijing National Laboratory for Molecular Sciences, CAS Laboratory of Colloid and Interface and Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Center for Carbon Neutral Chemistry) X Xinchen Kang (Institute of Chemistry, Chinese Academy of Sciences , , ,) X Xiaofu Sun (Beijing National Laboratory for Molecular Sciences, CAS Laboratory of Colloid and Interface and Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Center for Carbon Neutral Chemistry) Q Qinggong Zhu (Institute of Chemistry, Chinese Academy of Sciences , , ,) B Buxing Han (Institute of Chemistry, Chinese Academy of Sciences , , ,)

Abstract

AbstractElectrochemical synthesis has emerged as a sustainable platform in constructing C─N bonds for amino acid production. Glycine, a particularly valuable target compound, continues to experience escalating global demand, yet achieving simultaneous high efficiency and operational stability remains a persistent challenge. Herein, we demonstrate a CO2‐mediated strategy for glycine electrosynthesis using oxalic acid and N2/nitrate as feedstocks. By using Pb/Pb7Bi3‐CO2 catalytic system, a very high glycine Faradaic efficiency (FE) of 91.8% with durable stability over 120 h could be achieved. Moreover, when using nonthermal plasma‐activated N2 as the nitrogen source, the glycine production rate could maintain at 94.4 µmol h−1 cm−2 with N‐selectivity as high as 93.2%. Mechanistic investigations combining experiments and theoretical calculations reveal that CO2 undergoes facile protonation on the Pb/Pb7Bi3 heterointerfaces to form *OCOH intermediate, which donates hydrogen for the reduction of oxalic acid and nitrate into glyoxylic acid and NH2OH, respectively, while CO2 is simultaneously regenerated. Notably, hydrogenation via the *OCOH intermediate significantly lowers the energy barriers compared to direct protonation, thereby promoting the subsequent spontaneous C─N bond formation and enabling highly efficient electrosynthesis of glycine.

Article Details

Volume / Issue Vol. 64, Issue 40
Published September 26, 2025
ISSN 1433-7851
Publisher Wiley

Journal Info

Angewandte Chemie International Edition

Wiley

ISSN: 1433-7851 Physical Sciences

Authors (13)

P

Pengsong Li

Institute of Chemistry, Chinese Academy of Sciences , , ,

Y

Yong Wang

X

Xiangda Zhang

Beijing National Laboratory for Molecular Sciences, CAS Laboratory of Colloid and Interface and Thermodynamics, CAS Re‐search/Education Center for Excellence in Molecular Sciences, Center for Carbon Neutral Chemistry, Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P.R. China

C

Congyang Wang

University of Chinese Academy of Sciences , , ,

Y

Yuqing Hou

Institute of Chemistry, Chinese Academy of Sciences , , ,

G

Ganwen Zhang

Institute of Chemistry, Chinese Academy of Sciences , , ,

X

Xihua Wang

L

Lihong Jing

Beijing National Laboratory for Molecular Sciences, CAS Laboratory of Colloid and Interface and Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Center for Carbon Neutral Chemistry

Q

Qingli Qian

Beijing National Laboratory for Molecular Sciences, CAS Laboratory of Colloid and Interface and Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Center for Carbon Neutral Chemistry

X

Xinchen Kang

Institute of Chemistry, Chinese Academy of Sciences , , ,

X

Xiaofu Sun

Beijing National Laboratory for Molecular Sciences, CAS Laboratory of Colloid and Interface and Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Center for Carbon Neutral Chemistry

Q

Qinggong Zhu

Institute of Chemistry, Chinese Academy of Sciences , , ,

B

Buxing Han

Institute of Chemistry, Chinese Academy of Sciences , , ,