Effects of a multimodal physical therapy approach on breast cancer-related lymphedema: a retrospective pre-post study

D Divya varshini R M Mahalakshmi Venugopalan A Ashokan Arumugam F Filippo Migliorini N Nicola Maffulli R Rajkumar Kottayasamy Seenivasagam

Abstract

Abstract Despite the availability of numerous lymphedema treatments, integrating physical therapy for breast cancer-related lymphedema (BCRL) management has limited evidence. The objective is to evaluate the effect of a multimodal physical therapy approach in reducing upper limb (UL) lymphedema and improving shoulder range of motion (ROM) in women with BCRL. A retrospective study was conducted with 19 women diagnosed with BCRL. UL circumference and shoulder ROM were assessed before and after four weeks of therapy and showed significant improvement ( p  < 0.05). The mean difference between baseline and 4-week intervention was 2.11 cm for UL circumference (95% CI: 1.54, 2.68; Cohen’s d = 1.35), 46.31 o for shoulder flexion (95% CI -57.5, -35.1; Cohen’s d = 1.68), 10 o for shoulder extension (95% CI -13.4, -6.59; Cohen’s d = 1.74), 47.36 o for shoulder abduction (95% CI -60.35, -34.38; Cohen’s d = 1.67), 18.94 o for shoulder internal rotation (95% CI -24.4, -13.4; Cohen’s d = 1.37) and 16.05 o for shoulder external rotation (95% CI -20.03, -12.07; Cohen’s d = 1.51). Women with BCRL showed significant improvements in lymphedema and shoulder mobility following four weeks of therapy. Further, robust randomised clinical trials are required to substantiate these findings in Indian women.

Article Details

Volume / Issue Vol. 15, Issue 1
Published November 21, 2025
ISSN 2045-2322
Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (6)

D

Divya varshini R

M

Mahalakshmi Venugopalan

A

Ashokan Arumugam

F

Filippo Migliorini

N

Nicola Maffulli

R

Rajkumar Kottayasamy Seenivasagam