Effect of adverse outcomes—septicemias, healthcare complications, coagulopathies, and cardiac arrhythmias—on the burden of illness and related disparities among hospitalized cervical cancer patients afflicted by COVID-19.

Abstract

e17524 Background: Cervical cancer patients receiving cancer care are at significant risk of adverse health outcomes, specifically when compounded by co-occurring conditions such as COVID-19. We hypothesize that cervical malignancies impacted by COVID-19 will result in an escalation of adverse outcomes, exacerbating the burden of illness and accompanying inequities. This study aims to address this gap by analyzing the relationship between clinical results and their impact on BOI. Methods: We analyzed a cohort of cervical cancer patients hospitalized for cancer treatment and co -diagnosed with COVID-19 using 2021 National Inpatient Sample database from U.S. We utilized generalized linear models to assess the outcome of coagulopathies, cardiac arrhythmias, septicemia, mortality, neurological disorders and their association with BOI metrics, including length of stay (LOS), and total charge. Disparities were also evaluated. In the adjusted analysis, we controlled for clinical and patient-level variables. Results: Among 137840 patients with cervical cancer there was 36665 COVID infection. In the adjusted analysis, cervical cancer patients with COVID infection was associated with longer LOS (coef: 1.89; 95% CI 1.65-2.16); cost (total) (coef 1.38; 95%CI 1.25-1.52); in-hospital mortality (aOR: 2.97; 95% CI 2.30-3.84); septicemia (aOR: 1.71; 95% CI 1.42-2.06); healthcare associated complications including infectious complications (HAC) (aOR: 1.55; 95% CI 1.29-1.86); neurological disorders (aOR: 1.47; 95% CI 1.17-1.84); fluid and electrolyte imbalance (aOR: 1.49; 95% CI 1.25-1.77); coagulopathy (aOR: 1.83; 95% CI 1.49-2.26); cardiac arrythmias (aOR: 1.46; 95% CI 1.19-1.78). Compared to Whites, African Americans were associated with higher mortality (aOR: 1.22, 95%CI: 1.03-1.45) when affected with COVID-19. Compared to Whites, Hispanics were associated with higher septicemia (aOR: 1.24, 95%CI: 1.10-1.41) and HAC (aOR 1.17, 95%CI 1.04-1.32). Conclusions: The findings indicate that COVID-19 infections in individuals with cervical cancer elevate the risk of septicemia, mortality, and further coagulopathy and cardiac arrhythmia, along with other variables that exacerbate overall hospital burden. These findings underscore the necessity for enhanced medical assistance for cervical cancer patients impacted by COVID-19, particularly in relation to infectious complications, and cardiological conditions. At this time, patients who have been diagnosed with cervical cancer are still battling with COVID-19. African Americans and Hispanic women who have been diagnosed with cervical cancer have worse results in the study. In order to prevent such discrepancies and reduce the costs of healthcare, it is vital to do more investigation into these findings.