Dynamic properties of Kermack-McKendrick-like models

H Hamidou A. Diallo K Khalil Ezzinbi N Nisrine Outada G Gauthier Sallet

Abstract

We rigorously analyze the dynamic properties of Kermack-McKendrick-like compartmental models for infectious diseases, extending the classical SIR framework to include exposed individuals, mild and severe infections, hospitalization, and intensive care unit (ICU) compartments. Using a 13-compartment model, we establish mathematical results on well-posedness, the basic reproduction number R 0 , a first integral leading to a unique final epidemic size, and the global stability of the disease-free equilibrium under permanent immunity. When temporary immunity is included, we prove the existence of an endemic equilibrium for R 0  > 1. An age-stratified multi-group version of the model is also studied, demonstrating similar convergence properties and highlighting the impact of age structure on epidemic dynamics. Our results provide a rigorous mathematical framework for understanding how immunity duration, clinical progression, and age structure shape epidemic outcomes.

Article Details

Journal PLoS ONE
Volume / Issue Vol. 21, Issue 7
Published July 14, 2026
Pages e0352960
ISSN 1932-6203
Publisher Public Library of Science

Journal Info

PLoS ONE

Public Library of Science

ISSN: 1932-6203 Open Access Health Sciences

Authors (4)

H

Hamidou A. Diallo

K

Khalil Ezzinbi

N

Nisrine Outada

G

Gauthier Sallet