Journal of the American Chemical Society

Dual-Targeting Multivalent Aptamer-Drug Hybrids for Synergistic Cancer Immunotherapy

H Hongli Chi (Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)) Y Yanlin Du (Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)) W Wei Lv K Keli An (Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)) X Xinru Lv (Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)) S Sining Zhao (Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)) Y Yuchen Zeng (Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)) X Xinni Liu (Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)) P Pengju Li (Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)) W Wangbo Qu (Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)) C Chunyan Fan (Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)) Z Zeng Wang (Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)) A Anna S. Kichkailo (Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Aptamerlab LLC) T Ting Fu M Ming Cheng (Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)) P Penghui Zhang (Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)) W Weihong Tan (Institute of Molecular Medicine (IMM), Department of Nephrology, Molecular Cell Laboratory for Kidney Disease, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, School of Chemistry and Chemical Engineering)
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Article Details

Volume / Issue Vol. 148, Issue 15
Published April 22, 2026
Pages 15782-15796
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society
ISSN: 0002-7863 Physical Sciences

Authors (17)

H

Hongli Chi

Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)

Y

Yanlin Du

Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)

W

Wei Lv

K

Keli An

Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)

X

Xinru Lv

Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)

S

Sining Zhao

Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)

Y

Yuchen Zeng

Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)

X

Xinni Liu

Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)

P

Pengju Li

Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)

W

Wangbo Qu

Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)

C

Chunyan Fan

Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)

Z

Zeng Wang

Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)

A

Anna S. Kichkailo

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Aptamerlab LLC

T

Ting Fu

M

Ming Cheng

Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)

P

Penghui Zhang

Department of Clinical Laboratory, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM)

W

Weihong Tan

Institute of Molecular Medicine (IMM), Department of Nephrology, Molecular Cell Laboratory for Kidney Disease, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, School of Chemistry and Chemical Engineering

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