Dual Inhibitors of SARS-CoV-2 3CL Protease and Human Cathepsin L Containing Glutamine Isosteres Are Anti-CoV-2 Agents

V Vivek Kumar J Jiyun Zhu (Department of Pathology) B Bala C. Chenna (Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77845, United States) Z Zoe A. Hoffpauir A Andrew Rademacher (Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77845, United States) A Ashley M. Rogers (Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77845, United States) C Chien-Te Tseng (Department of Microbiology & Immunology Centers for Biodefense and Emerging Diseases, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, Texas 77555, United States) A Aleksandra Drelich (Department of Microbiology & Immunology Centers for Biodefense and Emerging Diseases, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, Texas 77555, United States) S Sharfa Farzandh (Department of Chemistry, University of Texas at San Antonio, 1 UTSA Circle, San Antonio, Texas 78249, United States) A Audrey L. Lamb T Thomas D. Meek (Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77845, United States)

Article Details

Volume / Issue Vol. 147, Issue 2
Published January 15, 2025
Pages 1631-1648
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (11)

V

Vivek Kumar

J

Jiyun Zhu

Department of Pathology

B

Bala C. Chenna

Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77845, United States

Z

Zoe A. Hoffpauir

A

Andrew Rademacher

Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77845, United States

A

Ashley M. Rogers

Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77845, United States

C

Chien-Te Tseng

Department of Microbiology & Immunology Centers for Biodefense and Emerging Diseases, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, Texas 77555, United States

A

Aleksandra Drelich

Department of Microbiology & Immunology Centers for Biodefense and Emerging Diseases, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, Texas 77555, United States

S

Sharfa Farzandh

Department of Chemistry, University of Texas at San Antonio, 1 UTSA Circle, San Antonio, Texas 78249, United States

A

Audrey L. Lamb

T

Thomas D. Meek

Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77845, United States