Double-dose firmonertinib as first-line treatment in patients with locally advanced or metastatic non-small-cell lung cancer harboring EGFR L858R mutation: a prospective, multicenter, phase II study (FIRM)

Bo Shen; Chun Wang; Liqin Zhang; Yingying Zhu; Xing Zhang; Xiaoxuan Wang; Zhen Guo; Li Wang; Xiaohua Wang; Liqun Zhu; Yun Zhou; Danting Liao; Meiqi Shi

doi:10.1038/s41467-026-68554-6

Double-dose firmonertinib as first-line treatment in patients with locally advanced or metastatic non-small-cell lung cancer harboring EGFR L858R mutation: a prospective, multicenter, phase II study (FIRM)

B Bo Shen (Department of Chemistry) C Chun Wang L Liqin Zhang Y Yingying Zhu X Xing Zhang (State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry) X Xiaoxuan Wang Z Zhen Guo (CAS Key Lab of Bio-Medical Diagnostics) L Li Wang (The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital Zhengzhou China) X Xiaohua Wang L Liqun Zhu Y Yun Zhou D Danting Liao M Meiqi Shi

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published January 19, 2026

DOI 10.1038/s41467-026-68554-6

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (13)

B

Bo Shen

Department of Chemistry

C

Chun Wang

L

Liqin Zhang

Y

Yingying Zhu

X

Xing Zhang

State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry

X

Xiaoxuan Wang

Z

Zhen Guo

CAS Key Lab of Bio-Medical Diagnostics

L

Li Wang

The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital Zhengzhou China

X

Xiaohua Wang

L

Liqun Zhu

Y

Yun Zhou

D

Danting Liao

M

Meiqi Shi

Double-dose firmonertinib as first-line treatment in patients with locally advanced or metastatic non-small-cell lung cancer harboring EGFR L858R mutation: a prospective, multicenter, phase II study (FIRM)

Article Details

Journal Info

Authors (13)

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