Disparities in outcomes of metastatic prostate cancer hospitalizations: 2008-2021.

Abstract

e13836 Background: Despite initial responses to therapy, metastatic prostate cancer remains a progressive and lethal disease that is associated with poor outcomes. Our aim was to identify trends in inpatient metastatic prostate cancer outcomes stratified by demographic subgroups. Methods: This is a retrospective longitudinal trends study using the Nationwide Inpatient Sample (NIS) database (2008-2021). We identified hospitalizations with metastatic prostate cancer using ICD-9 and ICD-10 codes. Using multivariate logistics and linear regression models we examined disparities in mortality outcomes stratified by age and race subgroups. Results: There were 787,169 hospitalizations with metastatic prostate cancer between 2008 and 2021. The mean age at hospitalization was 74 years. Most of the admissions occurred among older (≥65 years; 80%) patients who identified as non-Hispanic White (63%). There was an overall improvement in hospital mortality, from 8.3% in 2008 to 6.8% in 2021 (aOR: 0.99; P-trend = 0.001). In the age subgroup, only the older patient group (≥65 years) experienced a significant decline in mortality rate (aOR: 0.99; P-trend = 0.001). The younger adult population ( < 65 years) had no significant change in mortality rate (P-trend = 0.293). On racial subgroup analysis, only non-Hispanic White patients had a significant decline in mortality trend (aOR: 0.99; P-trend < 0.001) during the study period. Non-Hispanic Blacks (P-trend = 0.143) and Hispanics (P-trend = 0.731) patients had no significant change in mortality outcomes over the duration. Conclusions: There was an overall improvement in the mortality outcomes of metastatic prostate cancer hospitalizations. On sub-group analysis, a significant decline in mortality was seen among older and non-Hispanic White patients. Targeted studies and tailored therapies are needed to address these disparities in metastatic prostate cancer outcomes. Mortality trends of metastatic prostate cancer hospitalizations stratified by demographic subgroups. Mortality Adjusted odds ratio P-Trend 95% Confidence Interval Overall 0.99 0.001 0.984-0.996 Young adults (< 65 years) 0.99 0.29 0.98-1.006 Older adults (≥65 years) 0.99 0.001 0.983-0.996 Non-Hispanic White 0.985 <0.001 0.978-0.992 Black 0.99 0.143 0.978-1.003 Hispanic 1.0 0.731 0.977-1.016