Discovery of Noninhibitory Macrocyclic Ligands for Protein Tyrosine Phosphatase 1B Using a Function-Based, Iterative Screening Strategy
J
Jiajun Dong
(Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, 120 Scripps Way, Jupiter, Florida 33458, United States)
B
Bo Li
C
Chung-Wei Fu
(Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, 120 Scripps Way, Jupiter, Florida 33458, United States)
T
Thomas Kodadek
(Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, 120 Scripps Way, Jupiter, Florida 33458, United States)
Article Details
Volume / Issue
Vol. 1, Issue 1
Published
July 27, 2026
ISSN
0002-7863
Publisher
American Chemical Society
Journal Info
Journal of the American Chemical Society
American Chemical Society
ISSN: 0002-7863 Physical Sciences
Authors (4)
J
Jiajun Dong
Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, 120 Scripps Way, Jupiter, Florida 33458, United States
B
Bo Li
C
Chung-Wei Fu
Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, 120 Scripps Way, Jupiter, Florida 33458, United States
T
Thomas Kodadek
Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, 120 Scripps Way, Jupiter, Florida 33458, United States
Related Articles from this Journal
Rational Design of the Composite Perfluoro-Sulfonic Ionomer for High-Performance Proton Exchange Membrane Fuel Cells
Tingting Mao, Haiyang Fan et al.
Jul 2026
10.1021/jacs.6c05625
Ti3+-O Acid–Base Pairs for Efficient Solar-Driven Photothermal Nonoxidative Ethane Dehydrogenation
Yuwen Sun, Kun Gong et al.
Jul 2026
10.1021/jacs.6c08665
Total Synthesis of Benthol A: Evidence for a Structure Revision
Guanghao Huang, Andrea Tomio et al.
Jul 2026
10.1021/jacs.6c05580
Accelerated Self-Photopolymerization of Phenolics in Microdroplets Contributes to the Brown Carbon Formation
Haoran Yu, Xinrui Yang et al.
Jul 2026
10.1021/jacs.6c10186
Deciphering the Specificity of Reversible DNA-Phosphate ADP-Ribosylation via the Precise Synthesis and Enzymatic Profiling of Nucleotide-Phospho-ADP-Ribosyl Probes
Lingxiao Liu, Yang Lu et al.
Jul 2026
10.1021/jacs.6c02874