Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization

Z Zhijiao Zhang X Xiaoyu Shi T Ting Wu (Children’s Hospital, Zhejiang University School of Medicine) Z Zhuhan He R Ruipeng Liang W Wenjie Ye Z Zhenkun Wu (State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Affiliated Hospital of Hunan University, School of Biomedical Sciences) H Hui Liao F Fengxin Zheng Q Qian Yang Z Zean Zhao Y Yongjun Chen (Department of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China) Z Zhen Gao (State Key Laboratory of Optical Fiber and Cable Manufacturing Technology, Department of Electronic and Electrical Engineering, Guangdong Key Laboratory of Integrated Optoelectronics Intellisense, Southern University of Science and Technology) S Shuo Wang M Mei Wang (School of Materials Science and Engineering, Institute for New Energy Materials & Low Carbon Technologies) Z Zhenqian Wang D Danhui Qi M Mingyu Yang S Shujing Xu Y Youzhao Wang T Tong Zhao J Javier Egea X Xinyong Liu J Jianxin Pang F Fan Yi P Peng Zhan

Article Details

Volume / Issue Vol. 16, Issue 1
Published August 12, 2025
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (26)

Z

Zhijiao Zhang

X

Xiaoyu Shi

T

Ting Wu

Children’s Hospital, Zhejiang University School of Medicine

Z

Zhuhan He

R

Ruipeng Liang

W

Wenjie Ye

Z

Zhenkun Wu

State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Affiliated Hospital of Hunan University, School of Biomedical Sciences

H

Hui Liao

F

Fengxin Zheng

Q

Qian Yang

Z

Zean Zhao

Y

Yongjun Chen

Department of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China

Z

Zhen Gao

State Key Laboratory of Optical Fiber and Cable Manufacturing Technology, Department of Electronic and Electrical Engineering, Guangdong Key Laboratory of Integrated Optoelectronics Intellisense, Southern University of Science and Technology

S

Shuo Wang

M

Mei Wang

School of Materials Science and Engineering, Institute for New Energy Materials & Low Carbon Technologies

Z

Zhenqian Wang

D

Danhui Qi

M

Mingyu Yang

S

Shujing Xu

Y

Youzhao Wang

T

Tong Zhao

J

Javier Egea

X

Xinyong Liu

J

Jianxin Pang

F

Fan Yi

P

Peng Zhan