Journal of the American Chemical Society

Discovery of Carbodiimide Warheads to Selectively and Covalently Target Aspartic Acid in KRAS<sup>G12D</sup>

L Ludovica S. Sirocchi (Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria) M Maximilian Scharnweber (Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria) S Sarah Oberndorfer (Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria) G Gabriella Siszler (Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria) K Krzysztof M. Zak (Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria) K Klaus Rumpel (Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria) R Ralph A. Neumüller (Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria) B Birgit Wilding (Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria)
Download PDF View Original
APA MLA Chicago BibTeX RIS

Article Details

Volume / Issue Vol. 147, Issue 18
Published May 07, 2025
Pages 15787-15795
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society
ISSN: 0002-7863 Physical Sciences

Authors (8)

L

Ludovica S. Sirocchi

Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria

M

Maximilian Scharnweber

Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria

S

Sarah Oberndorfer

Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria

G

Gabriella Siszler

Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria

K

Krzysztof M. Zak

Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria

K

Klaus Rumpel

Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria

R

Ralph A. Neumüller

Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria

B

Birgit Wilding

Boehringer Ingelheim RCV GmbH & Co KG, Dr.-Boehringer-Gasse 5-11, Vienna A-1121, Austria

Related Articles from this Journal

Rational Design of the Composite Perfluoro-Sulfonic Ionomer for High-Performance Proton Exchange Membrane Fuel Cells

Tingting Mao, Haiyang Fan et al. Jul 2026 10.1021/jacs.6c05625

Ti3+-O Acid–Base Pairs for Efficient Solar-Driven Photothermal Nonoxidative Ethane Dehydrogenation

Yuwen Sun, Kun Gong et al. Jul 2026 10.1021/jacs.6c08665

Total Synthesis of Benthol A: Evidence for a Structure Revision

Guanghao Huang, Andrea Tomio et al. Jul 2026 10.1021/jacs.6c05580

Accelerated Self-Photopolymerization of Phenolics in Microdroplets Contributes to the Brown Carbon Formation

Haoran Yu, Xinrui Yang et al. Jul 2026 10.1021/jacs.6c10186

Deciphering the Specificity of Reversible DNA-Phosphate ADP-Ribosylation via the Precise Synthesis and Enzymatic Profiling of Nucleotide-Phospho-ADP-Ribosyl Probes

Lingxiao Liu, Yang Lu et al. Jul 2026 10.1021/jacs.6c02874