Discovery of a Two-Step Enzyme Cascade Converting Aspartate to Aminomalonate in Peptide Natural Product Biosynthesis

H Hye Won Kim (Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea) S Sangwook Kang (Natural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy) S Sihyeon Kim (Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea) H Hyunbin Lee Y Yegang Hur (Natural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Gwanak-gu, Seoul 08826, Republic of Korea) W Woon Ju Song (Department of Chemistry) D Dong-Chan Oh (Natural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy) S Seokhee Kim (Department of Chemistry and Natural Products Research Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea)

Article Details

Volume / Issue Vol. 147, Issue 24
Published June 18, 2025
Pages 20909-20918
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (8)

H

Hye Won Kim

Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea

S

Sangwook Kang

Natural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy

S

Sihyeon Kim

Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea

H

Hyunbin Lee

Y

Yegang Hur

Natural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Gwanak-gu, Seoul 08826, Republic of Korea

W

Woon Ju Song

Department of Chemistry

D

Dong-Chan Oh

Natural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy

S

Seokhee Kim

Department of Chemistry and Natural Products Research Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea