Journal of the American Chemical Society

Discovery of a Potent Antisarcopenia Drug Molecular Scaffold Derived from <i>Ligusticum chuanxiong</i> and Its Photochemical Synthesis

S Shuai Zhang L Lei Wang C Chen-Yang He (The Biomedical Translational Research Institute, Faculty of Medical Science) Y Yong-Bin Chen (College of Traditional Chinese Medicine) Y Yong-Heng Wang (Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research) Y Yi-Fang Li (Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research) R Rong-Rong He (Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research) Y Yi Ding X Xin-Luan Wang (Translational Medicine R&D Center, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology) Q Qing-Hua Zhou (The Biomedical Translational Research Institute, Faculty of Medical Science) X Xin-Sheng Yao (Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research) H Huan Zhao Q Qin-Li Wan (Department of Pathogen Biology, School of Medicine) J Jian Zou (Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research) H Hao Gao (Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research)
Download PDF View Original
APA MLA Chicago BibTeX RIS

Article Details

Volume / Issue Vol. 148, Issue 20
Published May 27, 2026
Pages 20520-20531
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society
ISSN: 0002-7863 Physical Sciences

Authors (15)

S

Shuai Zhang

L

Lei Wang

C

Chen-Yang He

The Biomedical Translational Research Institute, Faculty of Medical Science

Y

Yong-Bin Chen

College of Traditional Chinese Medicine

Y

Yong-Heng Wang

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research

Y

Yi-Fang Li

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research

R

Rong-Rong He

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research

Y

Yi Ding

X

Xin-Luan Wang

Translational Medicine R&D Center, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology

Q

Qing-Hua Zhou

The Biomedical Translational Research Institute, Faculty of Medical Science

X

Xin-Sheng Yao

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research

H

Huan Zhao

Q

Qin-Li Wan

Department of Pathogen Biology, School of Medicine

J

Jian Zou

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research

H

Hao Gao

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research

Related Articles from this Journal

Rational Design of the Composite Perfluoro-Sulfonic Ionomer for High-Performance Proton Exchange Membrane Fuel Cells

Tingting Mao, Haiyang Fan et al. Jul 2026 10.1021/jacs.6c05625

Ti3+-O Acid–Base Pairs for Efficient Solar-Driven Photothermal Nonoxidative Ethane Dehydrogenation

Yuwen Sun, Kun Gong et al. Jul 2026 10.1021/jacs.6c08665

Total Synthesis of Benthol A: Evidence for a Structure Revision

Guanghao Huang, Andrea Tomio et al. Jul 2026 10.1021/jacs.6c05580

Accelerated Self-Photopolymerization of Phenolics in Microdroplets Contributes to the Brown Carbon Formation

Haoran Yu, Xinrui Yang et al. Jul 2026 10.1021/jacs.6c10186

Deciphering the Specificity of Reversible DNA-Phosphate ADP-Ribosylation via the Precise Synthesis and Enzymatic Profiling of Nucleotide-Phospho-ADP-Ribosyl Probes

Lingxiao Liu, Yang Lu et al. Jul 2026 10.1021/jacs.6c02874