Discovery of a paralog-selective p300 protein degrader with potent anti-cancer activity in hematological malignancies

Marwa S. Asem; Yan Zhai; Xiaohong Song; Milad Rouhimoghadam; Sreenivas Punna; Fritz G. Buchanan; Daniel T. Cohen; Ryan McClure; Stephanie Sandoval; Anlu Chen; Shaun McLoughlin; Colin Woodford; Peter Kovar; Vlasios Manaves; Alla V. Korepanova; Justin M. Reitsma; Andrea Shergalis; Judith A. Ronau; Yifei Kong; Yu Shen; Jurgen Dinges

doi:10.1038/s41467-026-72635-x

Discovery of a paralog-selective p300 protein degrader with potent anti-cancer activity in hematological malignancies

M Marwa S. Asem Y Yan Zhai X Xiaohong Song M Milad Rouhimoghadam (Technology & Therapeutic Platforms, AbbVie Incorporated) S Sreenivas Punna F Fritz G. Buchanan D Daniel T. Cohen R Ryan McClure S Stephanie Sandoval A Anlu Chen S Shaun McLoughlin C Colin Woodford P Peter Kovar V Vlasios Manaves A Alla V. Korepanova J Justin M. Reitsma (Technology & Therapeutic Platforms) A Andrea Shergalis J Judith A. Ronau Y Yifei Kong Y Yu Shen J Jurgen Dinges

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published May 06, 2026

DOI 10.1038/s41467-026-72635-x

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (21)

M

Marwa S. Asem

Y

Yan Zhai

X

Xiaohong Song

M

Milad Rouhimoghadam

Technology & Therapeutic Platforms, AbbVie Incorporated

S

Sreenivas Punna

F

Fritz G. Buchanan

D

Daniel T. Cohen

R

Ryan McClure

S

Stephanie Sandoval

A

Anlu Chen

S

Shaun McLoughlin

C

Colin Woodford

P

Peter Kovar

V

Vlasios Manaves

A

Alla V. Korepanova

J

Justin M. Reitsma

Technology & Therapeutic Platforms

A

Andrea Shergalis

J

Judith A. Ronau

Y

Yifei Kong

Y

Yu Shen

J

Jurgen Dinges

Discovery of a paralog-selective p300 protein degrader with potent anti-cancer activity in hematological malignancies

Article Details

Journal Info

Authors (21)

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