Discovery and mechanism of a highly selective, antifungal acetyl-CoA synthetase inhibitor

A Andrew J. Jezewski K Katy M. Alden J Jonah Propp D Drashti G. Daraji C Charles L. Lail M Michael E. Heene A Andrew J. Fuller J Jeffery C. Ferreira L Lijun Liu (Protein Structure and X-ray Crystallography Laboratory, Structural Biology Center) K Kevin P. Battaile (New York Structural Biology Center) N Noelle S. Williams (Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States) B Bart L. Staker (Seattle Structural Genomics Center for Infectious Disease, Seattle Children’s Research Institute) S Scott Lovell (Department of Pathology) T Timothy J. Hagen D Damian J. Krysan

Article Details

Volume / Issue Vol. 16, Issue 1
Published October 14, 2025
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (15)

A

Andrew J. Jezewski

K

Katy M. Alden

J

Jonah Propp

D

Drashti G. Daraji

C

Charles L. Lail

M

Michael E. Heene

A

Andrew J. Fuller

J

Jeffery C. Ferreira

L

Lijun Liu

Protein Structure and X-ray Crystallography Laboratory, Structural Biology Center

K

Kevin P. Battaile

New York Structural Biology Center

N

Noelle S. Williams

Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States

B

Bart L. Staker

Seattle Structural Genomics Center for Infectious Disease, Seattle Children’s Research Institute

S

Scott Lovell

Department of Pathology

T

Timothy J. Hagen

D

Damian J. Krysan