Discovery and Biosynthesis of Lanthipeptides Featuring an Azepinoindole Scaffold by Radical <i>S</i> -Adenosylmethionine Enzyme-Catalyzed C–C Bond Formation

H Hong-Yan Wang (State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy) X Xiao-Tong Gong (State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy) J Jin-Long Lu (State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy) H Hang Xu W Wei-Kang Zhai (State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy) J Jiang Xiong (State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy) M Mingshuo Hu (State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy) J Jiao-Jiao Cui (State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy) K Kun Gao X Xinxiang Lei (State Key Laboratory of Natural Product Chemistry, Lanzhou Magnetic Resonance Center, College of Chemistry and Chemical Engineering) H Huan Qi (Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insect, College Life Science) L Lie-Feng Ma (College of Pharmaceutical Science) Z Zha-Jun Zhan (College of Pharmaceutical Science) T Tao Yu J Jianye Dai (State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy) S Shangwen Luo (State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy) J Jian-Min Yue (State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy) S Shi-Hui Dong (State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy)

Article Details

Volume / Issue Vol. 148, Issue 27
Published July 15, 2026
Pages 29336-29353
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (18)

H

Hong-Yan Wang

State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy

X

Xiao-Tong Gong

State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy

J

Jin-Long Lu

State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy

H

Hang Xu

W

Wei-Kang Zhai

State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy

J

Jiang Xiong

State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy

M

Mingshuo Hu

State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy

J

Jiao-Jiao Cui

State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy

K

Kun Gao

X

Xinxiang Lei

State Key Laboratory of Natural Product Chemistry, Lanzhou Magnetic Resonance Center, College of Chemistry and Chemical Engineering

H

Huan Qi

Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insect, College Life Science

L

Lie-Feng Ma

College of Pharmaceutical Science

Z

Zha-Jun Zhan

College of Pharmaceutical Science

T

Tao Yu

J

Jianye Dai

State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy

S

Shangwen Luo

State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy

J

Jian-Min Yue

State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy

S

Shi-Hui Dong

State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, School of Pharmacy