Directed Evolution of Threonine Aldolases for the Photobiocatalytic Synthesis of β-Branched-α-Tetrasubstituted and Other Noncanonical Amino Acids

T Tian-Ci Wang (Department of Chemistry and Biochemistry) X Xiangyu Zhang Z Zheng Zhang G Guodong Rao (Department of Chemistry) Z Zhiyu Bo (Department of Chemistry and Biochemistry) P Pei-Pei Xie (Department of Chemistry) J Jiedong Li (Department of Chemistry and Biochemistry) Q Qiang Yang (Synthetic Molecule Design and Development, Lilly Research Laboratories) X Xiaoyong Li (Synthetic Molecule Design and Development, Lilly Research Laboratories) R R. David Britt J Jiang Wang (Synthetic Molecule Design and Development, Lilly Research Laboratories) P Peng Liu Y Yang Yang

Article Details

Volume / Issue Vol. 148, Issue 21
Published June 03, 2026
Pages 21922-21932
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (13)

T

Tian-Ci Wang

Department of Chemistry and Biochemistry

X

Xiangyu Zhang

Z

Zheng Zhang

G

Guodong Rao

Department of Chemistry

Z

Zhiyu Bo

Department of Chemistry and Biochemistry

P

Pei-Pei Xie

Department of Chemistry

J

Jiedong Li

Department of Chemistry and Biochemistry

Q

Qiang Yang

Synthetic Molecule Design and Development, Lilly Research Laboratories

X

Xiaoyong Li

Synthetic Molecule Design and Development, Lilly Research Laboratories

R

R. David Britt

J

Jiang Wang

Synthetic Molecule Design and Development, Lilly Research Laboratories

P

Peng Liu

Y

Yang Yang