Direct-to-Biology Enabled Molecular Glue Discovery

M Maowei Hu (Department of Chemical Biology and Therapeutics) J Jason Ochoada (Lead Discovery Informatics Center, Department of Chemical Biology and Therapeutics) M Marisa Actis (Targeted Protein Degradation Center, Department of Chemical Biology and Therapeutics) K Kevin McGowan (Medicinal Chemistry Center, Department of Chemical Biology and Therapeutics) J Jamie A. Jarusiewicz (Targeted Protein Degradation Center, Department of Chemical Biology and Therapeutics) S Satoshi Yoshimura (Department of Pharmacy and Pharmaceutical Sciences) L Logan McGrath (Department of Pharmacy and Pharmaceutical Sciences) U Uma Neelakantan (Department of Chemical Biology and Therapeutics) A Anup Aggarwal (Targeted Protein Degradation Center, Department of Chemical Biology and Therapeutics) A Anand Mayasundari (Targeted Protein Degradation Center, Department of Chemical Biology and Therapeutics) S Sarah M. Young (Department of Chemical Biology and Therapeutics) M Meng Zhang L Lei Yang Y Yong Li S Shea Mercer (Program Management, Department of Chemical Biology and Therapeutics) M M. Madan Babu (Center of Excellence for Data Driven Discovery, Department of Structural Biology) M Marcus Fischer B Brandon M. Young (Medicinal Chemistry Center, Department of Chemical Biology and Therapeutics) J Jun J. Yang (Department of Pharmacy and Pharmaceutical Sciences) G Gisele Nishiguchi (Targeted Protein Degradation Center, Department of Chemical Biology and Therapeutics) A Anang A. Shelat (Lead Discovery Informatics Center, Department of Chemical Biology and Therapeutics) D Daniel J. Blair

Article Details

Volume / Issue Vol. 148, Issue 1
Published January 14, 2026
Pages 20-27
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (22)

M

Maowei Hu

Department of Chemical Biology and Therapeutics

J

Jason Ochoada

Lead Discovery Informatics Center, Department of Chemical Biology and Therapeutics

M

Marisa Actis

Targeted Protein Degradation Center, Department of Chemical Biology and Therapeutics

K

Kevin McGowan

Medicinal Chemistry Center, Department of Chemical Biology and Therapeutics

J

Jamie A. Jarusiewicz

Targeted Protein Degradation Center, Department of Chemical Biology and Therapeutics

S

Satoshi Yoshimura

Department of Pharmacy and Pharmaceutical Sciences

L

Logan McGrath

Department of Pharmacy and Pharmaceutical Sciences

U

Uma Neelakantan

Department of Chemical Biology and Therapeutics

A

Anup Aggarwal

Targeted Protein Degradation Center, Department of Chemical Biology and Therapeutics

A

Anand Mayasundari

Targeted Protein Degradation Center, Department of Chemical Biology and Therapeutics

S

Sarah M. Young

Department of Chemical Biology and Therapeutics

M

Meng Zhang

L

Lei Yang

Y

Yong Li

S

Shea Mercer

Program Management, Department of Chemical Biology and Therapeutics

M

M. Madan Babu

Center of Excellence for Data Driven Discovery, Department of Structural Biology

M

Marcus Fischer

B

Brandon M. Young

Medicinal Chemistry Center, Department of Chemical Biology and Therapeutics

J

Jun J. Yang

Department of Pharmacy and Pharmaceutical Sciences

G

Gisele Nishiguchi

Targeted Protein Degradation Center, Department of Chemical Biology and Therapeutics

A

Anang A. Shelat

Lead Discovery Informatics Center, Department of Chemical Biology and Therapeutics

D

Daniel J. Blair