Direct Therapeutic Modulation of RYR2 Activity by CMYA5

F Fujian Lu (Institutes of Biomedical Sciences, Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, China (F.L., Y.W., C.C., B.S., Z.G.).) Z Zexuan Wu (Key Laboratory of Power Station Energy Transfer Conversion and System of Ministry of Education School of Energy Power and Mechanical Engineering North China Electric Power University Beijing 102206 China) S Shaopeng Chi (Department of Cardiology, Boston Children’s Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).) Y Yangong Wang A Anna Ponek (Department of Cardiology, Boston Children’s Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).) Q Qing Ma (DND-CAT, Synchrotron Research Center, Northwestern University, Evanston, Illinois 60208, United States) C Chunjing Chen B Bingbing Shi N Nikoleta Pavlaki (Department of Cardiology, Boston Children’s Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).) C Carter Liou (Department of Cardiology, Boston Children’s Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).) Y Yashasvi Tharani M Maksymilian Prondzynski S Sanam Shafaat Talab (Department of Cardiology, Boston Children’s Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).) W Wenjun Xie Y Yu Seby Chen Z Zengpin Guo (Institutes of Biomedical Sciences, Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, China (F.L., Y.W., C.C., B.S., Z.G.).) S Stuart R. Lipsitz (Department of Cardiology, Boston Children’s Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).) D Donghui Zhang (State Key Laboratory of Bioreactor Engineering) F Filip Van Petegem V Vassilios J. Bezzerides W William T. Pu

Article Details

Journal Circulation
Volume / Issue Vol. 152, Issue 16
Published October 21, 2025
Pages 1179-1182
ISSN 0009-7322
Publisher Lippincott Williams & Wilkins

Journal Info

Circulation

Lippincott Williams & Wilkins

ISSN: 0009-7322 Health Sciences

Authors (21)

F

Fujian Lu

Institutes of Biomedical Sciences, Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, China (F.L., Y.W., C.C., B.S., Z.G.).

Z

Zexuan Wu

Key Laboratory of Power Station Energy Transfer Conversion and System of Ministry of Education School of Energy Power and Mechanical Engineering North China Electric Power University Beijing 102206 China

S

Shaopeng Chi

Department of Cardiology, Boston Children’s Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).

Y

Yangong Wang

A

Anna Ponek

Department of Cardiology, Boston Children’s Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).

Q

Qing Ma

DND-CAT, Synchrotron Research Center, Northwestern University, Evanston, Illinois 60208, United States

C

Chunjing Chen

B

Bingbing Shi

N

Nikoleta Pavlaki

Department of Cardiology, Boston Children’s Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).

C

Carter Liou

Department of Cardiology, Boston Children’s Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).

Y

Yashasvi Tharani

M

Maksymilian Prondzynski

S

Sanam Shafaat Talab

Department of Cardiology, Boston Children’s Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).

W

Wenjun Xie

Y

Yu Seby Chen

Z

Zengpin Guo

Institutes of Biomedical Sciences, Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, China (F.L., Y.W., C.C., B.S., Z.G.).

S

Stuart R. Lipsitz

Department of Cardiology, Boston Children’s Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).

D

Donghui Zhang

State Key Laboratory of Bioreactor Engineering

F

Filip Van Petegem

V

Vassilios J. Bezzerides

W

William T. Pu