Direct Access to Chiral Tertiary Alcohols via Copper-Catalyzed Enantioconvergent
                    <i>O</i>
                    -Alkylation of Water with Racemic α-Tertiary Haloamides

Jia-Yong Zhang; Pei-Jie Huang; Si-Yuan Chen; Cheng Luan; Qiang-Shuai Gu; Biao Wang; Yu-Feng Zhang; Chang-Jiang Yang; Ji-Jun Chen; Xin-Yuan Liu

doi:10.1021/jacs.6c08724

Journal of the American Chemical Society

Direct Access to Chiral Tertiary Alcohols via Copper-Catalyzed Enantioconvergent <i>O</i> -Alkylation of Water with Racemic α-Tertiary Haloamides

J Jia-Yong Zhang (Department of Chemistry, School of Sciences and Guangdong Provincial Key Laboratory of Mathematical and Neural Dynamical Systems) P Pei-Jie Huang (Department of Chemistry, School of Sciences and Guangdong Provincial Key Laboratory of Mathematical and Neural Dynamical Systems) S Si-Yuan Chen (Department of Chemistry, School of Sciences and Guangdong Provincial Key Laboratory of Mathematical and Neural Dynamical Systems) C Cheng Luan (New Cornerstone Science Laboratory, Shenzhen Grubbs Institute, Department of Chemistry, and Guangming Advanced Research Institute) Q Qiang-Shuai Gu (New Cornerstone Science Laboratory, Shenzhen Grubbs Institute, Department of Chemistry, and Guangming Advanced Research Institute) B Biao Wang (New Cornerstone Science Laboratory, Shenzhen Grubbs Institute, Department of Chemistry, and Guangming Advanced Research Institute) Y Yu-Feng Zhang (New Cornerstone Science Laboratory, Shenzhen Grubbs Institute, Department of Chemistry, and Guangming Advanced Research Institute) C Chang-Jiang Yang (Department of Chemistry, School of Sciences and Guangdong Provincial Key Laboratory of Mathematical and Neural Dynamical Systems) J Ji-Jun Chen (New Cornerstone Science Laboratory, Shenzhen Grubbs Institute, Department of Chemistry, and Guangming Advanced Research Institute) X Xin-Yuan Liu (New Cornerstone Science Laboratory, Shenzhen Grubbs Institute, Department of Chemistry, and Guangming Advanced Research Institute)

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Article Details

Journal Journal of the American Chemical Society

Volume / Issue Vol. 148, Issue 26

Published July 08, 2026

Pages 27848-27857

DOI 10.1021/jacs.6c08724

ISSN 0002-7863

Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (10)

J

Jia-Yong Zhang

Department of Chemistry, School of Sciences and Guangdong Provincial Key Laboratory of Mathematical and Neural Dynamical Systems

P

Pei-Jie Huang

Department of Chemistry, School of Sciences and Guangdong Provincial Key Laboratory of Mathematical and Neural Dynamical Systems

S

Si-Yuan Chen

Department of Chemistry, School of Sciences and Guangdong Provincial Key Laboratory of Mathematical and Neural Dynamical Systems

C

Cheng Luan