Dioxazolones as Masked Isocyanate Electrophiles for Global Profiling of Lysine Reactivity and Ligandability

Y Yanxia Feng (State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China) S Shihan Zeng (State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China) F Fang Xu (Key Laboratory of Optoelectronic Chemical Materials and Devices (Ministry of Education), School of Optoelectronic Materials and Technology) W Weizhen Huang (The First Huizhou Affiliated Hospital of Guangdong Medical University) S Shengrong Li (State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China) Y Yi Tan (State Key Laboratory of Bioactive Molecules and Druggability Assessment, and School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China) Z Zhengqiu Li (State Key Laboratory of Bioactive Molecules and Druggability Assessment, and School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China)

Article Details

Volume / Issue Vol. 147, Issue 50
Published December 17, 2025
Pages 46550-46562
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (7)

Y

Yanxia Feng

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China

S

Shihan Zeng

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China

F

Fang Xu

Key Laboratory of Optoelectronic Chemical Materials and Devices (Ministry of Education), School of Optoelectronic Materials and Technology

W

Weizhen Huang

The First Huizhou Affiliated Hospital of Guangdong Medical University

S

Shengrong Li

State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China

Y

Yi Tan

State Key Laboratory of Bioactive Molecules and Druggability Assessment, and School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China

Z

Zhengqiu Li

State Key Laboratory of Bioactive Molecules and Druggability Assessment, and School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China