Diabetes mellitus and <i>APOL1</i> genotype increase the risk for chronic kidney disease progression in sickle cell disease
Abstract
Abstract We observed diabetes mellitus (DM) in 9.3% of adults with sickle cell disease (SCD), and DM predicted a sevenfold greater risk of chronic kidney disease progression adjusting for high-risk APOL1. Our results emphasize the clinical significance of DM in SCD.
Article Details
Authors (12)
Ryan Sun
Anand Srivastava
Joseph L. Zapater
3Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL
Franklin Njoku
1University of Illinois Chicago, Chicago, United States
Jin Han
Zalaya Ivy
1Comprehensive Sickle Cell Center, Division of Hematology and Oncology, Department of Medicine, University of Illinois Chicago, Chicago, IL
Marwah Farooqui
1University of Illinois College of Medicine, Chicago, United States
Insia Rizvi
1Division of Hematology and Oncology, Department of Medicine, University of Illinois Chicago, Chicago, IL
Brian Layden
University of Illinois Chicago, Chicago, Illinois, United States
Robert E. Molokie
1Division of Hematology and Oncology, Department of Medicine, University of Illinois Chicago, Chicago, IL
Victor R. Gordeuk
Santosh L. Saraf
1Comprehensive Sickle Cell Center, Division of Hematology and Oncology, Department of Medicine, University of Illinois Chicago, Chicago, IL