Development of Substrate-Directed Activity-Based Probes via Disulfide-Trapping for Site-Specific Interrogation of Nucleosomal Deubiquitination

Z Zaozhen He (School of Pharmaceutical Sciences, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Shanghai Frontiers Science Center of Drug Target Identification and Delivery) Y Yuantong Huo (Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry) Y Yanling Zhang (School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, The State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure) S Shixian Tao (Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry) Y Yun Liu Z Zhiheng Deng (Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry) X Xiaolin Tian (MOE Key Laboratory of Bioinformatics, School of Life Sciences) X Xinyu Lan (Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry) H Haiteng Deng (MOE Key Laboratory of Bioinformatics, School of Life Sciences) L Lei Liu W Wei Qin (International Joint Research Laboratory of Nano-Micro Architecture Chemistry, Institute of Theoretical Chemistry and College of Chemistry) H Huasong Ai (School of Pharmaceutical Sciences, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Center for Chemical Glycobiology-Zhangjiang Institute for Advanced Study, Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Research Center for Chemical Biology of Post-translational Modifications)

Article Details

Volume / Issue Vol. 148, Issue 6
Published February 18, 2026
Pages 6485-6497
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (12)

Z

Zaozhen He

School of Pharmaceutical Sciences, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Shanghai Frontiers Science Center of Drug Target Identification and Delivery

Y

Yuantong Huo

Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry

Y

Yanling Zhang

School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, The State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure

S

Shixian Tao

Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry

Y

Yun Liu

Z

Zhiheng Deng

Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry

X

Xiaolin Tian

MOE Key Laboratory of Bioinformatics, School of Life Sciences

X

Xinyu Lan

Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry

H

Haiteng Deng

MOE Key Laboratory of Bioinformatics, School of Life Sciences

L

Lei Liu

W

Wei Qin

International Joint Research Laboratory of Nano-Micro Architecture Chemistry, Institute of Theoretical Chemistry and College of Chemistry

H

Huasong Ai

School of Pharmaceutical Sciences, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Center for Chemical Glycobiology-Zhangjiang Institute for Advanced Study, Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Research Center for Chemical Biology of Post-translational Modifications