Development of FBXO22 Degraders and the Recruitment Ligand 2-Pyridinecarboxyaldehyde (2-PCA)

T Tian Qiu (Department of Chemical and Systems Biology, ChEM-H and Stanford Cancer Institute, Stanford Medical School) Z Zhe Zhuang (Department of Chemical and Systems Biology, ChEM-H and Stanford Cancer Institute, Stanford Medical School) W Woong Sub Byun (Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine) Z Zuzanna Kozicka (Department of Medical Oncology) K Kheewoong Baek (Department of Cancer Biology, Dana–Farber Cancer Institute, Boston, MA 02215, USA.) J Jianing Zhong (Department of Chemistry) A Abby M. Thornhill (Department of Cancer Biology) J Julia K. Ryan (Department of Cancer Biology) K Katherine A. Donovan E Eric S. Fischer B Benjamin L. Ebert (Department of Medical Oncology) N Nathanael S. Gray

Article Details

Volume / Issue Vol. 147, Issue 49
Published December 10, 2025
Pages 45132-45144
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (12)

T

Tian Qiu

Department of Chemical and Systems Biology, ChEM-H and Stanford Cancer Institute, Stanford Medical School

Z

Zhe Zhuang

Department of Chemical and Systems Biology, ChEM-H and Stanford Cancer Institute, Stanford Medical School

W

Woong Sub Byun

Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine

Z

Zuzanna Kozicka

Department of Medical Oncology

K

Kheewoong Baek

Department of Cancer Biology, Dana–Farber Cancer Institute, Boston, MA 02215, USA.

J

Jianing Zhong

Department of Chemistry

A

Abby M. Thornhill

Department of Cancer Biology

J

Julia K. Ryan

Department of Cancer Biology

K

Katherine A. Donovan

E

Eric S. Fischer

B

Benjamin L. Ebert

Department of Medical Oncology

N

Nathanael S. Gray