Development of Dual-Receptor Lysosome-Targeting Chimeras for Protein Degradation

K Kun Wang (Beijing National Laboratory for Molecular Science, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering) K Ke Wang (Tianjin Medical University Cancer Institute and Hospital Tianjin China) C Cong Wang (Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066) H Hange Yang (Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066) G Gangzhong Zhou (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) P Peihong Ji (Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066) X Xudong Sun (Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066) G Gong Chen (State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry) X Xuegong Fan (Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066) K Kuan Hu J Juan Yi (Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066) H Hailong Zhang R Rui Wang

Article Details

Volume / Issue Vol. 147, Issue 44
Published November 05, 2025
Pages 40751-40762
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (13)

K

Kun Wang

Beijing National Laboratory for Molecular Science, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering

K

Ke Wang

Tianjin Medical University Cancer Institute and Hospital Tianjin China

C

Cong Wang

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066

H

Hange Yang

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066

G

Gangzhong Zhou

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

P

Peihong Ji

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066

X

Xudong Sun

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066

G

Gong Chen

State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry

X

Xuegong Fan

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066

K

Kuan Hu

J

Juan Yi

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066

H

Hailong Zhang

R

Rui Wang