Deubiquitinase-Targeting Chimeras Mediated Stabilization of Tumor Suppressive E3 Ligase Proteins as a Strategy for Cancer Therapy

L Li Chen Z Zhijie Deng (Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute) Y Yan Xiong J Jing Liu D Daoyuan Huang (Department of Pathology) J Jingchao Wang (Department of Pathology) Y Yong Chen H Hiroyuki Inuzuka (RIKEN Center for Emergent Matter Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) L Ling Xie X Xian Chen J Jian Jin W Wenyi Wei (Department of Pathology)

Article Details

Volume / Issue Vol. 147, Issue 33
Published August 20, 2025
Pages 29875-29883
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (12)

L

Li Chen

Z

Zhijie Deng

Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute

Y

Yan Xiong

J

Jing Liu

D

Daoyuan Huang

Department of Pathology

J

Jingchao Wang

Department of Pathology

Y

Yong Chen

H

Hiroyuki Inuzuka

RIKEN Center for Emergent Matter Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

L

Ling Xie

X

Xian Chen

J

Jian Jin

W

Wenyi Wei

Department of Pathology