Designing Molecular Reactor of Interlayer Dual‐Atom Toward Urea Electrosynthesis

K Kefan Zhang (State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Advanced Catalytic Engineering Research Center of the Ministry of Education) Y Yuyan Liu X Xupeng Qin (National Synchrotron Radiation Laboratory) P Peilian Hou (State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Advanced Catalytic Engineering Research Center of the Ministry of Education) C Chu Zhang (MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, State Key Laboratory of Space Power-Sources, School of Chemistry and Chemical Engineering) D Dafeng Yan (Hubei Key Laboratory for Precision Synthesis of Small Molecule Pharmaceuticals & Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering) C Chade Lv (MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, State Key Laboratory of Space Power-Sources, School of Chemistry and Chemical Engineering) D Dawei Chen (State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Advanced Catalytic Engineering Research Center of the Ministry of Education) Y Yong Feng Z Ze Wu Y Yujie Wang (Shenyang National Laboratory for Materials Science, Institute of Metal Research) S Shuxuan Liu (State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering) Y Yingjie Li Y Yongpan Hu (Soochow Institute for Energy and Materials Innovations (SIEMIS), Jiangsu Key Laboratory for Carbon‐Based Func‐tional Materials & Devices Soochow University Suzhou 215006 P.R. China) K Kun Feng (Institute of Functional Nano and Soft Materials Laboratory (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices) J Jun Zhong (Institute of Functional Nano and Soft Materials Laboratory (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices) Q Qinghua Liu (National Synchrotron Radiation Laboratory) C Chen Chen S Shuangyin Wang (State Key Laboratory of Chem/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering)

Abstract

Abstract Electrocatalytic C─N coupling offers a sustainable alternative to energy‐intensive industrial processes for urea synthesis. Herein, we design conjugated polymer‐based molecular reactors featuring interlayer diatomic Cu–N 4 sites and precisely tunable spacings (4.0, 4.6, and 5.7 Å) to optimize CO 2 and nitrate coupling. The 4.0 Å‐spaced copper polyphthalocyanine (CuPPc‐4.0) delivers a remarkable urea yield rate of 460.0 mmol h −1  g −1 with 26.1% Faradaic efficiency at −1.3 V (versus RHE), outperforming wider‐spaced analogs. The optimal 4.0 Å cavity spatially confines reactants and intermediates, matching urea's molecular dimensions (3.5 Å), thereby enhancing C–N coupling and urea synthesis activity, while the layered AA stacking structure stabilizes unbonded diatomic Cu configurations, preventing aggregation and ensuring durability. Mechanistic studies reveal that while ball‐milling treatment increases single‐atom exposure, it disrupts the layered architecture and eliminates interlayer diatomic sites, reducing activity by about 50%. This work demonstrates a multidimensional catalyst design integrating atomic precision and molecular confinement for sustainable electrosynthesis.

Article Details

Volume / Issue Vol. 64, Issue 38
Published September 15, 2025
ISSN 1433-7851
Publisher Wiley

Journal Info

Angewandte Chemie International Edition

Wiley

ISSN: 1433-7851 Physical Sciences

Authors (19)

K

Kefan Zhang

State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Advanced Catalytic Engineering Research Center of the Ministry of Education

Y

Yuyan Liu

X

Xupeng Qin

National Synchrotron Radiation Laboratory

P

Peilian Hou

State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Advanced Catalytic Engineering Research Center of the Ministry of Education

C

Chu Zhang

MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, State Key Laboratory of Space Power-Sources, School of Chemistry and Chemical Engineering

D

Dafeng Yan

Hubei Key Laboratory for Precision Synthesis of Small Molecule Pharmaceuticals & Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering

C

Chade Lv

MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, State Key Laboratory of Space Power-Sources, School of Chemistry and Chemical Engineering

D

Dawei Chen

State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Advanced Catalytic Engineering Research Center of the Ministry of Education

Y

Yong Feng

Z

Ze Wu

Y

Yujie Wang

Shenyang National Laboratory for Materials Science, Institute of Metal Research

S

Shuxuan Liu

State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering

Y

Yingjie Li

Y

Yongpan Hu

Soochow Institute for Energy and Materials Innovations (SIEMIS), Jiangsu Key Laboratory for Carbon‐Based Func‐tional Materials & Devices Soochow University Suzhou 215006 P.R. China

K

Kun Feng

Institute of Functional Nano and Soft Materials Laboratory (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices

J

Jun Zhong

Institute of Functional Nano and Soft Materials Laboratory (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices

Q

Qinghua Liu

National Synchrotron Radiation Laboratory

C

Chen Chen

S

Shuangyin Wang

State Key Laboratory of Chem/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering