Design of Ig-like binders targeting α-synuclein fibril for mitigating its pathological activities

S Shuyi Zeng X Xingyu Xiong H Houfang Long (Interdisciplinary Research Center on Biology and Chemistry, State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry) Q Qianhui Xu Y Yifan Yu (College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, National Laboratory of Solid State Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Chemistry and Biomedicine Innovation Center, Collaborative Innovation Center of Advanced Microstructures) B Bo Sun C Cong Liu Z Zhizhi Wang (School of Life Science and Technology, ShanghaiTech University) W Wenqing Xu S Shengnan Zhang (Interdisciplinary Research Center on Biology and Chemistry, State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry) D Dan Li

Article Details

Volume / Issue Vol. 16, Issue 1
Published August 09, 2025
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (11)

S

Shuyi Zeng

X

Xingyu Xiong

H

Houfang Long

Interdisciplinary Research Center on Biology and Chemistry, State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry

Q

Qianhui Xu

Y

Yifan Yu

College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, National Laboratory of Solid State Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Chemistry and Biomedicine Innovation Center, Collaborative Innovation Center of Advanced Microstructures

B

Bo Sun

C

Cong Liu

Z

Zhizhi Wang

School of Life Science and Technology, ShanghaiTech University

W

Wenqing Xu

S

Shengnan Zhang

Interdisciplinary Research Center on Biology and Chemistry, State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry

D

Dan Li