Design and Semisynthesis of Ubiquitin Extension Probes for Structural Analysis of Cullin1-Mediated Substrate Polyubiquitination

C Chuntong Li (Center for Bioanalytical Chemistry, Hefei National Laboratory of Physical Science at Microscale) F Fangyu Zhao (Center for Bioanalytical Chemistry, Hefei National Laboratory of Physical Science at Microscale) C Chong Zuo (Beijing Life Science Academy) L Liying Zhang (Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry) Y Yangwode Jing (Beijing Life Science Academy) X Xu Li G Guo-Chao Chu (School of Food and Biological Engineering, Engineering Research Center of Bio-process, Ministry of Education) L Luyu Shi (Center for Bioanalytical Chemistry, Hefei National Laboratory of Physical Science at Microscale) Y Yingyue Zhang (Center for Bioanalytical Chemistry, Hefei National Laboratory of Physical Science at Microscale) H Han Wang S Shuzhe Sun (Beijing Life Science Academy) M Maoshen Sun (Howard Hughes Medical Institute, Department of Cell Biology) H Huasong Ai (School of Pharmaceutical Sciences, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Center for Chemical Glycobiology-Zhangjiang Institute for Advanced Study, Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Research Center for Chemical Biology of Post-translational Modifications) L Lu-Jun Liang (Center for Bioanalytical Chemistry, Hefei National Laboratory of Physical Science at Microscale) J Jinghong Li (Department of Chemistry, Center for Bioanalytical Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology)

Article Details

Volume / Issue Vol. 147, Issue 27
Published July 09, 2025
Pages 23878-23890
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (15)

C

Chuntong Li

Center for Bioanalytical Chemistry, Hefei National Laboratory of Physical Science at Microscale

F

Fangyu Zhao

Center for Bioanalytical Chemistry, Hefei National Laboratory of Physical Science at Microscale

C

Chong Zuo

Beijing Life Science Academy

L

Liying Zhang

Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry

Y

Yangwode Jing

Beijing Life Science Academy

X

Xu Li

G

Guo-Chao Chu

School of Food and Biological Engineering, Engineering Research Center of Bio-process, Ministry of Education

L

Luyu Shi

Center for Bioanalytical Chemistry, Hefei National Laboratory of Physical Science at Microscale

Y

Yingyue Zhang

Center for Bioanalytical Chemistry, Hefei National Laboratory of Physical Science at Microscale

H

Han Wang

S

Shuzhe Sun

Beijing Life Science Academy

M

Maoshen Sun

Howard Hughes Medical Institute, Department of Cell Biology

H

Huasong Ai

School of Pharmaceutical Sciences, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Center for Chemical Glycobiology-Zhangjiang Institute for Advanced Study, Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Research Center for Chemical Biology of Post-translational Modifications

L

Lu-Jun Liang

Center for Bioanalytical Chemistry, Hefei National Laboratory of Physical Science at Microscale

J

Jinghong Li

Department of Chemistry, Center for Bioanalytical Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology