Deleterious variants in the autophagy-related gene RB1CC1/FIP200 impair immunity to SARS-CoV-2

L Lili Hu R Renee M. van der Sluis K Kennith Brian Castelino B Bao-Cun Zhang A Andreas Ronit T Thomas Zillinger (Department of Biomedicine, Aarhus University) M Marvin Werner S Sofie Eg Jørgensen (Department of Biomedicine, Aarhus University) A Anne Louise Hansen (Department of Biomedicine, Aarhus University) A Alice Pedersen R Ryo Narita L Line S. Reinert B Bettina Bundgaard L Laurent Abel (St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University) A Alessandro Aiuti S Saleh Al-Muhsen F Fahd Al-Mulla M Mark S. Anderson E Evangelos Andreakos (Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens) A Andrés A. Arias L Lisa M. Arkin H Hagit Baris Feldman P Paul Bastard (Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children) A Alexandre Belot C Catherine M. Biggs D Dusan Bogunovic A Alexandre Bolze A Anastasiia Bondarenko A Alessandro Borghesi A Ahmed A. Bousfiha P Petter Brodin Y Yenan Bryceson G Giorgio Casari J John Christodoulou R Roger Colobran A Antonio Condino-Neto S Stefan N. Constantinescu M Megan A. Cooper C Clifton L. Dalgard M Murkesh Desai B Beth A. Drolet M Munis Dündar X Xavier Duval S Sotirija Duvlis J Jamila El Baghdadi P Philippine Eloy S Sara Espinosa-Padilla J Jacques Fellay C Carlos Flores J José Luis Franco A Antoine Froidure G Guy Gorochov (Pitie Salpetriere Hospital, Departement de Sante Publique and Sorbonne University, INSERM, Institut Pierre Louis d‘Epidemiologie et de Sante Publique) M Marta Gut F Filomeen Haerynck D David Hagin R Rabih Halwani L Lennart Hammarström (Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute) J James R. Heath E Elena W. Y. Hsieh E Eystein Husebye K Kohsuke Imai Y Yuval Itan E Emmanuelle Jouanguy E Elżbieta Kaja T Timokratis Karamitros K Kai Kisand C Cheng-Lung Ku Y Yu-Lung Lau Y Yun Ling C Carrie L. Lucas (Immunobiology Department, Yale University School of Medicine) M Matthieu Mahévas D Davood Mansouri L László Maródi F France Mentré I Isabelle Meyts J Joshua D. Milner K Kristina Mironska T Tomohiro Morio L Lisa F. P. Ng L Luigi D. Notarangelo A Antonio Novelli G Giuseppe Novelli C Cliona O’Farrelly S Satoshi Okada K Keisuke Okamoto T Tayfun Ozcelik F Firat Ozcelik Q Qiang Pan-Hammarström (Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute) R Rebeca Pérez de Diego (Institute of Biomedical Research of IdiPAZ, University Hospital “La Paz”) J Jordi Pérez-Tur D David S. Perlin J Jonny Peter (Division of Allergology and Clinical Immunology, Department of Medicine, Groote Schuur Hospital, University of Cape Town and Allergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa) A Anna M. Planas C Carolina Prando A Aurora Pujol (Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute, L’Hospitalet de Llobregat) A Anne Puel L Lluis Quintana-Murci S Sathishkumar Ramaswamy L Laurent Renia I Igor Resnick C Carlos Rodríguez-Gallego V Vanessa Sancho-Shimizu A Anna Sediva M Mikko R. J. Seppänen M Mohammad Shahrooei A Anna Shcherbina O Ondrej Slaby A Andrew L. Snow P Pere Soler-Palacín V Vassili Soumelis A András N. Spaan H Helen C. Su I Ivan Tancevski S Stuart G. Tangye A Ahmad Abou Tayoun Şehime Gülsün Temel C Christian Thorball P Pierre Tiberghien S Sophie Trouillet-Assant S Stuart E. Turvey K K. M. Furkan Uddin M Mohammed J. Uddin D Diederik van de Beek F Fernanda Sales Luiz Vianna (Genomic Medicine, Experimental Research Center, Hospital de Clínicas de Porto Alegre) D Donald C. Vinh H Horst von Bernuth J Joost Wauters M Mayana Zatz Q Qian Zhang S Shen-Ying Zhang (St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University) J Jacob Bodilsen K Kristoffer Skaalum Hansen M Merete Storgaard (Department of Infectious Diseases, Aarhus University Hospital) T Thomas Benfield M Marie Helleberg C Christian K. Holm A Aurélie Cobat (St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University) J Jean-Laurent Casanova F Fulvio Reggiori M Muriel Mari S Søren R. Paludan T Trine H. Mogensen (Department of Biomedicine, Aarhus University)

Article Details

Volume / Issue Vol. 16, Issue 1
Published November 27, 2025
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (142)

L

Lili Hu

R

Renee M. van der Sluis

K

Kennith Brian Castelino

B

Bao-Cun Zhang

A

Andreas Ronit

T

Thomas Zillinger

Department of Biomedicine, Aarhus University

M

Marvin Werner

S

Sofie Eg Jørgensen

Department of Biomedicine, Aarhus University

A

Anne Louise Hansen

Department of Biomedicine, Aarhus University

A

Alice Pedersen

R

Ryo Narita

L

Line S. Reinert

B

Bettina Bundgaard

L

Laurent Abel

St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University

A

Alessandro Aiuti

S

Saleh Al-Muhsen

F

Fahd Al-Mulla

M

Mark S. Anderson

E

Evangelos Andreakos

Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens

A

Andrés A. Arias

L

Lisa M. Arkin

H

Hagit Baris Feldman

P

Paul Bastard

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children

A

Alexandre Belot

C

Catherine M. Biggs

D

Dusan Bogunovic

A

Alexandre Bolze

A

Anastasiia Bondarenko

A

Alessandro Borghesi

A

Ahmed A. Bousfiha

P

Petter Brodin

Y

Yenan Bryceson

G

Giorgio Casari

J

John Christodoulou

R

Roger Colobran

A

Antonio Condino-Neto

S

Stefan N. Constantinescu

M

Megan A. Cooper

C

Clifton L. Dalgard

M

Murkesh Desai

B

Beth A. Drolet

M

Munis Dündar

X

Xavier Duval

S

Sotirija Duvlis

J

Jamila El Baghdadi

P

Philippine Eloy

S

Sara Espinosa-Padilla

J

Jacques Fellay

C

Carlos Flores

J

José Luis Franco

A

Antoine Froidure

G

Guy Gorochov

Pitie Salpetriere Hospital, Departement de Sante Publique and Sorbonne University, INSERM, Institut Pierre Louis d‘Epidemiologie et de Sante Publique

M

Marta Gut

F

Filomeen Haerynck

D

David Hagin

R

Rabih Halwani

L

Lennart Hammarström

Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute

J

James R. Heath

E

Elena W. Y. Hsieh

E

Eystein Husebye

K

Kohsuke Imai

Y

Yuval Itan

E

Emmanuelle Jouanguy

E

Elżbieta Kaja

T

Timokratis Karamitros

K

Kai Kisand

C

Cheng-Lung Ku

Y

Yu-Lung Lau

Y

Yun Ling

C

Carrie L. Lucas

Immunobiology Department, Yale University School of Medicine

M

Matthieu Mahévas

D

Davood Mansouri

L

László Maródi

F

France Mentré

I

Isabelle Meyts

J

Joshua D. Milner

K

Kristina Mironska

T

Tomohiro Morio

L

Lisa F. P. Ng

L

Luigi D. Notarangelo

A

Antonio Novelli

G

Giuseppe Novelli

C

Cliona O’Farrelly

S

Satoshi Okada

K

Keisuke Okamoto

T

Tayfun Ozcelik

F

Firat Ozcelik

Q

Qiang Pan-Hammarström

Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute

R

Rebeca Pérez de Diego

Institute of Biomedical Research of IdiPAZ, University Hospital “La Paz”

J

Jordi Pérez-Tur

D

David S. Perlin

J

Jonny Peter

Division of Allergology and Clinical Immunology, Department of Medicine, Groote Schuur Hospital, University of Cape Town and Allergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa

A

Anna M. Planas

C

Carolina Prando

A

Aurora Pujol

Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute, L’Hospitalet de Llobregat

A

Anne Puel

L

Lluis Quintana-Murci

S

Sathishkumar Ramaswamy

L

Laurent Renia

I

Igor Resnick

C

Carlos Rodríguez-Gallego

V

Vanessa Sancho-Shimizu

A

Anna Sediva

M

Mikko R. J. Seppänen

M

Mohammad Shahrooei

A

Anna Shcherbina

O

Ondrej Slaby

A

Andrew L. Snow

P

Pere Soler-Palacín

V

Vassili Soumelis

A

András N. Spaan

H

Helen C. Su

I

Ivan Tancevski

S

Stuart G. Tangye

A

Ahmad Abou Tayoun

Şehime Gülsün Temel

C

Christian Thorball

P

Pierre Tiberghien

S

Sophie Trouillet-Assant

S

Stuart E. Turvey

K

K. M. Furkan Uddin

M

Mohammed J. Uddin

D

Diederik van de Beek

F

Fernanda Sales Luiz Vianna

Genomic Medicine, Experimental Research Center, Hospital de Clínicas de Porto Alegre

D

Donald C. Vinh

H

Horst von Bernuth

J

Joost Wauters

M

Mayana Zatz

Q

Qian Zhang

S

Shen-Ying Zhang

St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University

J

Jacob Bodilsen

K

Kristoffer Skaalum Hansen

M

Merete Storgaard

Department of Infectious Diseases, Aarhus University Hospital

T

Thomas Benfield

M

Marie Helleberg

C

Christian K. Holm

A

Aurélie Cobat

St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University

J

Jean-Laurent Casanova

F

Fulvio Reggiori

M

Muriel Mari

S

Søren R. Paludan

T

Trine H. Mogensen

Department of Biomedicine, Aarhus University