Defect‐Guided Assembly of Aperiodic and Flexible Metal–Organic Frameworks From Pre‐Formed Cages

F Francisco Sánchez‐Férez (Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Barcelona Spain) A Akim Khobotov‐Bakishev (Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Barcelona Spain) B Borja Ortín‐Rubio (Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Barcelona Spain) C Cornelia von Baeckman (Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Barcelona Spain) L Laura Hernández‐López (Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Barcelona Spain) A Alba Cortés‐Martínez (Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Barcelona Spain) R Robert A. I. Paraoan (Inorganic Chemistry Laboratory Department of Chemistry University of Oxford Oxford UK) R Roberto Boada (Department of Chemistry Faculty of Science Universitat Autònoma de Barcelona (UAB) Barcelona Spain) J Judith Juanhuix (ALBA Synchrotron Light Facility Barcelona Spain) F Felipe Gándara (Materials Science Institute of Madrid, CSIC, Sor Juana Inés de la Cruz 3, Madrid 28049, Spain) A Andrew L. Goodwin (Department of Chemistry, Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QR, U.K.) A Arnau Carné‐Sánchez (Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Barcelona Spain) D Daniel Maspoch (Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, and The Barcelona Institute of Science and Technology)

Abstract

ABSTRACT Controlling the spatial distribution of defects in metal–organic frameworks (MOFs) remains a fundamental challenge in defect engineering. Here, we report a cage‐directed assembly strategy that enables the programmed introduction of topologically correlated defects and induces aperiodicity in HKUST‐1‐type frameworks. Pre‐synthesised Rh(II) metal–organic cages or polyhedra (MOPs) act as persistent cavities that template the formation of HKUST‐1‐based networks containing linker‐induced Cu‐vacancy domains confined within discrete cuboctahedral cavities. The use of dicarboxylate linkers, in which one carboxylate group is missing compared to the original 1,3,5‐benzenetricarboxylate linker, gives rise to nine distinct local defect configurations that are independently distributed throughout the lattice. This results in an aperiodic framework with preserved long‐range crystallinity. The resulting materials exhibit hierarchical micro–mesoporosity, reversible loss and recovery of crystallinity, and a pronounced solvent‐induced breathing response. This work demonstrates that combining pre‐formed cages with linkers with reduced connectivity can be a new strategy to localise defects and access aperiodic MOFs with emergent structural adaptability.

Article Details

Volume / Issue Vol. 1, Issue 1
Published June 26, 2026
ISSN 1433-7851
Publisher Wiley

Journal Info

Angewandte Chemie International Edition

Wiley

ISSN: 1433-7851 Physical Sciences

Authors (13)

F

Francisco Sánchez‐Férez

Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Barcelona Spain

A

Akim Khobotov‐Bakishev

Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Barcelona Spain

B

Borja Ortín‐Rubio

Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Barcelona Spain

C

Cornelia von Baeckman

Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Barcelona Spain

L

Laura Hernández‐López

Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Barcelona Spain

A

Alba Cortés‐Martínez

Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Barcelona Spain

R

Robert A. I. Paraoan

Inorganic Chemistry Laboratory Department of Chemistry University of Oxford Oxford UK

R

Roberto Boada

Department of Chemistry Faculty of Science Universitat Autònoma de Barcelona (UAB) Barcelona Spain

J

Judith Juanhuix

ALBA Synchrotron Light Facility Barcelona Spain

F

Felipe Gándara

Materials Science Institute of Madrid, CSIC, Sor Juana Inés de la Cruz 3, Madrid 28049, Spain

A

Andrew L. Goodwin

Department of Chemistry, Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QR, U.K.

A

Arnau Carné‐Sánchez

Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Barcelona Spain

D

Daniel Maspoch

Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, and The Barcelona Institute of Science and Technology