De novo design of hypercompact transcript degraders by engineering substrate-specific toxins and Cas6-CBS system

P Pin-Ru Chen P Pei-Pei Qin Y Ya-Nan Wang (School of Interdisciplinary Science) P Peng-Fu Liu X Xin-Yue Zhang (The College of Basic Medical Science, Health Sciences Institute, China Medical University) T Tao Qian (School of Chemistry and Chemical Engineering, Nantong Key Laboratory of Green Hydrogen-Ammonia Energy Storage and Conversion) B Bang-Ce Ye (Laboratory of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering) B Bin-Cheng Yin (Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering)

Article Details

Volume / Issue Vol. 16, Issue 1
Published September 26, 2025
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (8)

P

Pin-Ru Chen

P

Pei-Pei Qin

Y

Ya-Nan Wang

School of Interdisciplinary Science

P

Peng-Fu Liu

X

Xin-Yue Zhang

The College of Basic Medical Science, Health Sciences Institute, China Medical University

T

Tao Qian

School of Chemistry and Chemical Engineering, Nantong Key Laboratory of Green Hydrogen-Ammonia Energy Storage and Conversion

B

Bang-Ce Ye

Laboratory of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering

B

Bin-Cheng Yin

Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering