CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting

Ari Itoh-Nakadai; Minggao Liang; Michiho Shindo; Chen Bibi; Mariko Tomizawa-Murasawa; Saera Fujiki; Akiko Kaneko; Emi Kanamaru; Mari Hashimoto; Hiroshi Kajita; Yoshinari Ando; Miki Kojima; Jonathan Moody; Makoto Iwasaki; Shinsuke Takagi; Ryo Nakagawa; Saumya Agrawal; Hanae Amitani-Iijima; Kaori Sato; Yuriko Sorimachi; Nahoko Suzuki; Takehiro Fukami; Kazuharu Hanada; Satoshi Morita; Kazushige Katsura; Takehisa Matsumoto; Maiko Kobayashi; Masahiko Kato; Yasuyuki Negishi; Mikako Shirouzu; Yuho Najima; Keiyo Takubo; Chung Chau Hon; Naoyuki Uchida; Shuichi Taniguchi; Yukihide Momozawa; Piero Carninci; Leonard D. Shultz; Yoriko Saito; Michiel de Hoon; Jay W. Shin; Fumihiko Ishikawa

doi:10.1038/s41467-025-67745-x

CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting

A Ari Itoh-Nakadai M Minggao Liang M Michiho Shindo C Chen Bibi M Mariko Tomizawa-Murasawa S Saera Fujiki A Akiko Kaneko E Emi Kanamaru M Mari Hashimoto H Hiroshi Kajita Y Yoshinari Ando (RIKEN Center for Integrative Medical Sciences) M Miki Kojima J Jonathan Moody (RIKEN Center for Integrative Medical Sciences) M Makoto Iwasaki S Shinsuke Takagi R Ryo Nakagawa S Saumya Agrawal H Hanae Amitani-Iijima K Kaori Sato Y Yuriko Sorimachi N Nahoko Suzuki T Takehiro Fukami K Kazuharu Hanada S Satoshi Morita K Kazushige Katsura T Takehisa Matsumoto M Maiko Kobayashi M Masahiko Kato Y Yasuyuki Negishi M Mikako Shirouzu Y Yuho Najima K Keiyo Takubo C Chung Chau Hon (RIKEN Center for Integrative Medical Sciences) N Naoyuki Uchida S Shuichi Taniguchi Y Yukihide Momozawa P Piero Carninci L Leonard D. Shultz Y Yoriko Saito M Michiel de Hoon J Jay W. Shin (RIKEN Center for Integrative Medical Sciences) F Fumihiko Ishikawa

Download PDF View Original

APA MLA Chicago BibTeX RIS

Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published January 26, 2026

DOI 10.1038/s41467-025-67745-x

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (42)

A

Ari Itoh-Nakadai

M

Minggao Liang

M

Michiho Shindo

C

Chen Bibi

M

Mariko Tomizawa-Murasawa

S

Saera Fujiki

A

Akiko Kaneko

E

Emi Kanamaru

M

Mari Hashimoto

H

Hiroshi Kajita

Y

Yoshinari Ando

RIKEN Center for Integrative Medical Sciences

M

Miki Kojima

J

Jonathan Moody

RIKEN Center for Integrative Medical Sciences

M

Makoto Iwasaki

S

Shinsuke Takagi

R

Ryo Nakagawa

S

Saumya Agrawal

H

Hanae Amitani-Iijima

K

Kaori Sato

Y

Yuriko Sorimachi

N

Nahoko Suzuki

T

Takehiro Fukami

K

Kazuharu Hanada

S

Satoshi Morita

K

Kazushige Katsura

T

Takehisa Matsumoto

M

Maiko Kobayashi

M

Masahiko Kato

Y

Yasuyuki Negishi

M

Mikako Shirouzu

Y

Yuho Najima

K

Keiyo Takubo

C

Chung Chau Hon

RIKEN Center for Integrative Medical Sciences

N

Naoyuki Uchida

S

Shuichi Taniguchi

Y

Yukihide Momozawa

P

Piero Carninci

L

Leonard D. Shultz

Y

Yoriko Saito

M

Michiel de Hoon

J

Jay W. Shin

RIKEN Center for Integrative Medical Sciences

F

Fumihiko Ishikawa

CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting

Article Details

Journal Info

Authors (42)

Related Articles from this Journal

Synthesis of adaptive 15N-nitrosyl-Co7 nanocluster for electrocatalytic C–H functionalization

Pan-Ebolavirus nanoparticle vaccine provides protection in rodents from lethal infection by Zaire and Sudan viruses

Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk

Genome-wide annotation of human multi-nucleotide variants reveals widespread functional differences from single nucleotide variants

Allele-specific chromatin architecture shapes imprinted domains and coordinates a distal enhancer and antisense transcription at the mouse Mest-Copg2 domain