Cu‐Sn Biphasic Alloy Heterostructure With <i>p‐d</i> Orbital Hybridization for Efficient Electrosynthesis of Amino Acids

K Kaixing Cai (MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE For Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat‐Sen University Guangzhou China) J Jiahui Xian S Shilin Bo (MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE For Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat‐Sen University Guangzhou China) H Haixin Sun R Runan Xiang (MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE For Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat‐Sen University Guangzhou China) W Wenpei Liao (MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE For Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat‐Sen University Guangzhou China) Q Qinghua Liu (National Synchrotron Radiation Laboratory) G Guangqin Li (MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE For Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat‐Sen University Guangzhou China)

Abstract

ABSTRACT The electrocatalytic conversion of NO x species into amino acids is an attractive approach. However, significant challenges lie in the matching kinetics of C−N coupling and high selectivity for the target product. Herein, a Cu 3 Sn/Cu 6 Sn 5 biphasic alloy heterostructure (Cu‐Sn BAH) with p‐d orbital hybridization has been constructed by phase control engineering for enhanced amino acid electrosynthesis, delivering a remarkable glycine Faradaic efficiency of 80% and a selectivity of 93% at −0.8 V vs. RHE. Experimental and mechanistic studies reveal that the strong p‐d orbital hybridization between d ‐block Cu and p ‐block Sn effectively modulates interfacial electronic structure between Cu 3 Sn and Cu 6 Sn 5 biphasic alloys, promoting the electron transfer and optimizing the adsorption of NO 3– and glyoxylic acid, and thus facilitating the generation of *NH 2 OH with reduced energy barriers and subsequent oxime hydrogenation. This work offers a distinctive electrocatalyst design strategy for highly selective amino acid synthesis via orbital engineering and heterostructure construction, and also encourages the development of C−N coupling systems.

Article Details

Volume / Issue Vol. 65, Issue 19
Published May 04, 2026
ISSN 1433-7851
Publisher Wiley

Journal Info

Angewandte Chemie International Edition

Wiley

ISSN: 1433-7851 Physical Sciences

Authors (8)

K

Kaixing Cai

MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE For Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat‐Sen University Guangzhou China

J

Jiahui Xian

S

Shilin Bo

MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE For Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat‐Sen University Guangzhou China

H

Haixin Sun

R

Runan Xiang

MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE For Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat‐Sen University Guangzhou China

W

Wenpei Liao

MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE For Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat‐Sen University Guangzhou China

Q

Qinghua Liu

National Synchrotron Radiation Laboratory

G

Guangqin Li

MOE Laboratory of Bioinorganic and Synthetic Chemistry GBRCE For Functional Molecular Engineering Lehn Institute of Functional Materials School of Chemistry Sun Yat‐Sen University Guangzhou China