Journal of the American Chemical Society

Crystallizing the Uncrystallizable: Insights from Extensive Screening of PROTACs

M Martin A. Screen (Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.) J James F. McCabe (Early Pharmaceutical Development & Manufacture, Pharmaceutical Sciences) S Sean Askin (Advanced Drug Delivery, Pharmaceutical Sciences) J Jamie L. Guest (Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.) P Paul Hodgkinson (Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.) A Aurora J. Cruz-Cabeza (Department of Chemistry, Durham University, Stockton Road, Durham DH1 3LE, U.K.) T Toby J. Blundell D Daniel N. Rainer (School of Chemistry and Chemical Engineering, University of Southampton, Highfield, Southampton SO17 1BJ, U.K.) S Simon J. Coles (National Crystallography Service) A Alexandra Longcake (School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Kings Road, Newcastle upon Tyne NE1 7RU, U.K.) M Michael R. Probert (School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Kings Road, Newcastle upon Tyne NE1 7RU, U.K.) C Clare S. Mahon (Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.) M Mark R. Wilson (Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.) J Jonathan W. Steed (Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.)
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Article Details

Volume / Issue Vol. 147, Issue 31
Published August 06, 2025
Pages 28056-28072
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society
ISSN: 0002-7863 Physical Sciences

Authors (14)

M

Martin A. Screen

Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.

J

James F. McCabe

Early Pharmaceutical Development & Manufacture, Pharmaceutical Sciences

S

Sean Askin

Advanced Drug Delivery, Pharmaceutical Sciences

J

Jamie L. Guest

Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.

P

Paul Hodgkinson

Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.

A

Aurora J. Cruz-Cabeza

Department of Chemistry, Durham University, Stockton Road, Durham DH1 3LE, U.K.

T

Toby J. Blundell

D

Daniel N. Rainer

School of Chemistry and Chemical Engineering, University of Southampton, Highfield, Southampton SO17 1BJ, U.K.

S

Simon J. Coles

National Crystallography Service

A

Alexandra Longcake

School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Kings Road, Newcastle upon Tyne NE1 7RU, U.K.

M

Michael R. Probert

School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Kings Road, Newcastle upon Tyne NE1 7RU, U.K.

C

Clare S. Mahon

Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.

M

Mark R. Wilson

Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.

J

Jonathan W. Steed

Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.

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