Cryo-EM structures of UBA6 reveal mechanisms of E1–E2 specificity and dual FAT10/ubiquitin thioester transfer

Digant Nayak; Lijia Jia; Priscila dos Santos Bury; Eliza A. Ruben; Ankita Shukla; Anindita Nayak; Caleb M. Stratton; Pirouz Ebadi; Hee Cho; Anna A. Tumanova; Joyce T. Varughese; Lingmin Yuan; Fei Gao; Kristin E. Cano; Christopher Davies; Patrick Sung; Michaela U. Gack; Elizabeth V. Wasmuth; Shaun K. Olsen

doi:10.1038/s41467-026-69882-3

Cryo-EM structures of UBA6 reveal mechanisms of E1–E2 specificity and dual FAT10/ubiquitin thioester transfer

D Digant Nayak L Lijia Jia P Priscila dos Santos Bury E Eliza A. Ruben A Ankita Shukla A Anindita Nayak C Caleb M. Stratton P Pirouz Ebadi H Hee Cho A Anna A. Tumanova (Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio) J Joyce T. Varughese L Lingmin Yuan F Fei Gao K Kristin E. Cano C Christopher Davies P Patrick Sung M Michaela U. Gack E Elizabeth V. Wasmuth S Shaun K. Olsen

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published February 28, 2026

DOI 10.1038/s41467-026-69882-3

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (19)

D

Digant Nayak

L

Lijia Jia

P

Priscila dos Santos Bury

E

Eliza A. Ruben

A

Ankita Shukla

A

Anindita Nayak

C

Caleb M. Stratton

P

Pirouz Ebadi

H

Hee Cho

A

Anna A. Tumanova

Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio

J

Joyce T. Varughese

L

Lingmin Yuan

F

Fei Gao

K

Kristin E. Cano

C

Christopher Davies

P

Patrick Sung

M

Michaela U. Gack

E

Elizabeth V. Wasmuth

S

Shaun K. Olsen

Cryo-EM structures of UBA6 reveal mechanisms of E1–E2 specificity and dual FAT10/ubiquitin thioester transfer

Article Details

Journal Info

Authors (19)

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