CRISPR screening reveals that RNA helicase DDX41 triggers ribosome biogenesis and cancer progression through R-loop-mediated RPL/RPS transcription

H Hongquan Li (Department of Bioengineering) Y Yifei He J Jiawen Jiang Z Zhen Liu Y Yizhe Liu Q Qili Shi J Jie Ding (Max Planck Institute of Microstructure Physics) H Haochen Li W Weili Sun (Johnson & Johnson, Los Angeles) X Xin Hu Z Zhiao Chen X Xianghuo He (Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University)

Article Details

Volume / Issue Vol. 16, Issue 1
Published August 11, 2025
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (12)

H

Hongquan Li

Department of Bioengineering

Y

Yifei He

J

Jiawen Jiang

Z

Zhen Liu

Y

Yizhe Liu

Q

Qili Shi

J

Jie Ding

Max Planck Institute of Microstructure Physics

H

Haochen Li

W

Weili Sun

Johnson & Johnson, Los Angeles

X

Xin Hu

Z

Zhiao Chen

X

Xianghuo He

Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University