Journal of the American Chemical Society

Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design

S Sandra Kovachka (Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology (UF-Scripps), 130 Scripps Way, Jupiter, Florida 33458, United States) J Jielei Wang (The Scripps Research Institute, Department of Chemistry, 130 Scripps Way, Jupiter, Florida 33458, United States) A Amirhossein Taghavi (Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology (UF-Scripps), 130 Scripps Way, Jupiter, Florida 33458, United States) Y Yilin Jia (Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, Florida 33458, United States) T Taro Asaba (Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology (UF-Scripps), 130 Scripps Way, Jupiter, Florida 33458, United States) K Karen C. Wolff M Mason Martin (Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology (UF-Scripps), 130 Scripps Way, Jupiter, Florida 33458, United States) X Xueyi Yang (Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, Florida 33458, United States) S Samantha M. Meyer (Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology (UF-Scripps), 130 Scripps Way, Jupiter, Florida 33458, United States) S Sabine Ottilie (Calibr-Skaggs Institute for Innovation Medicines at Scripps Research) M Mina Heacock Z Zhong Cheng (State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Advanced Catalytic Engineering Research Center of the Ministry of Education) C Case W. McNamara G Gurudutt Dubey (Centro de Investigación Traslacional San Alberto Magno) A Arnab K. Chatterjee S Sumit Chanda J José Gallego (Centro de Investigación Traslacional San Alberto Magno) J Jessica L. Childs-Disney (The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Department of Chemistry, 130 Scripps Way, Jupiter, Florida 33458, United States) M Matthew D. Disney (Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, Florida 33458, United States)
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Article Details

Volume / Issue Vol. 147, Issue 41
Published October 15, 2025
Pages 37460-37479
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society
ISSN: 0002-7863 Physical Sciences

Authors (19)

S

Sandra Kovachka

Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology (UF-Scripps), 130 Scripps Way, Jupiter, Florida 33458, United States

J

Jielei Wang

The Scripps Research Institute, Department of Chemistry, 130 Scripps Way, Jupiter, Florida 33458, United States

A

Amirhossein Taghavi

Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology (UF-Scripps), 130 Scripps Way, Jupiter, Florida 33458, United States

Y

Yilin Jia

Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, Florida 33458, United States

T

Taro Asaba

Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology (UF-Scripps), 130 Scripps Way, Jupiter, Florida 33458, United States

K

Karen C. Wolff

M

Mason Martin

Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology (UF-Scripps), 130 Scripps Way, Jupiter, Florida 33458, United States

X

Xueyi Yang

Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, Florida 33458, United States

S

Samantha M. Meyer

Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology (UF-Scripps), 130 Scripps Way, Jupiter, Florida 33458, United States

S

Sabine Ottilie

Calibr-Skaggs Institute for Innovation Medicines at Scripps Research

M

Mina Heacock

Z

Zhong Cheng

State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Advanced Catalytic Engineering Research Center of the Ministry of Education

C

Case W. McNamara

G

Gurudutt Dubey

Centro de Investigación Traslacional San Alberto Magno

A

Arnab K. Chatterjee

S

Sumit Chanda

J

José Gallego

Centro de Investigación Traslacional San Alberto Magno

J

Jessica L. Childs-Disney

The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Department of Chemistry, 130 Scripps Way, Jupiter, Florida 33458, United States

M

Matthew D. Disney

Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, Florida 33458, United States

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