Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in a Hippo-dependent cancer model

T Thijs J. Hagenbeek (Department of Discovery Oncology, Genentech) J Jason Zbieg R Russell Smith S Sayantanee Paul (Department of Discovery Oncology, Genentech) L Luca Gerosa C Consuelo Torrini A Alissa D. Guarnaccia (Department of Proteomic and Genomic Technologies, Genentech) C Christy Ong J Jennifer A. Lacap M Miaoran Ning N Nicole M. Sodir M Marc Hafner J Julien Tremblay J James Hawley B Bryan Chan V Vishal A. Verma R Ramsay E. Beveridge P Peter L. Hsu G Gözde Ulas (Department of Biochemical and Cellular Pharmacology, Genentech) L Lisha Wang (Michigan Center for Translational Pathology, University of Michigan) J Jim Nonomiya S Shu Chen V Victoria Pham J Joshua Webster J Jessica Preston J Jeff Hung J Jeff Eastham D Debra Dunlap (Pathology, Genentech) W Wendy Lee (Department of Discovery Chemistry, Genentech) P Paul Beroza N Naema Nayyar S Scott Martin E Eva Lin (Merck Center for Catalysis at Princeton University) J Julie Weng S Scott A. Foster F Frances Shanahan R Rina Fong G Gladys Boenig P Paola Di Lello M Marta H. Kubala T Thomas Hunsaker M Mirunalini Ravichandran P Pablo Saenz-Lopez Larrocha J Jeffrey Lau L Le An E Elizabeth Levy M Maria N. Lorenzo J Jennie R. Lill (Department of Proteomic and Genomic Technologies, Genentech) Z Zora D. Modrusan Y Yi-Chen Chen X Xiaosai Yao P Priscilla K. Brastianos (Massachusetts General Hospital Cancer Center Boston Massachusetts USA) D Danilo Maddalo A Anwesha Dey (Department of Discovery Oncology, Genentech)