Covalent Inhibitors of Monoacylglycerol Lipase Induce Conformational Changes and Proteasomal Degradation

J Jordan A. Pham (Department of Chemistry and Biomolecular Sciences) T Thanawat Thaingtamtanha (Department of Chemistry and Biomolecular Sciences) W William McLeish (Department of Chemistry and Biomolecular Sciences) D David Lefebvre (Department of Chemistry and Biomolecular Sciences) S Spencer M. Uguccioni (Department of Chemistry and Biomolecular Sciences) R Roxana Filip (Department of Chemistry and Biomolecular Sciences) F Francesco Gentile (Department of Chemistry and Biomolecular Sciences) J John Paul Pezacki (Department of Chemistry and Biomolecular Sciences)

Article Details

Volume / Issue Vol. 148, Issue 19
Published May 20, 2026
Pages 19631-19642
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (8)

J

Jordan A. Pham

Department of Chemistry and Biomolecular Sciences

T

Thanawat Thaingtamtanha

Department of Chemistry and Biomolecular Sciences

W

William McLeish

Department of Chemistry and Biomolecular Sciences

D

David Lefebvre

Department of Chemistry and Biomolecular Sciences

S

Spencer M. Uguccioni

Department of Chemistry and Biomolecular Sciences

R

Roxana Filip

Department of Chemistry and Biomolecular Sciences

F

Francesco Gentile

Department of Chemistry and Biomolecular Sciences

J

John Paul Pezacki

Department of Chemistry and Biomolecular Sciences